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PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study

Programmed death-1 (PD-1) is crucial in cancer and is well characterized as a negative T-cell regulator that functions by delivering inhibitory signals. We aimed to evaluate the relationship between PD-1 polymorphisms (rs10204525, rs2227982, and rs7421861) and breast cancer risk. We selected 560 bre...

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Autores principales: Ren, Hong-Tao, Li, Yi-Ming, Wang, Xi-Jing, Kang, Hua-Feng, Jin, Tian-Bo, Ma, Xiao-Bin, Liu, Xing-Han, Wang, Meng, Liu, Kang, Xu, Peng, Yao, Qing-Ling, Dai, Zhi-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902368/
https://www.ncbi.nlm.nih.gov/pubmed/27227944
http://dx.doi.org/10.1097/MD.0000000000003760
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author Ren, Hong-Tao
Li, Yi-Ming
Wang, Xi-Jing
Kang, Hua-Feng
Jin, Tian-Bo
Ma, Xiao-Bin
Liu, Xing-Han
Wang, Meng
Liu, Kang
Xu, Peng
Yao, Qing-Ling
Dai, Zhi-Jun
author_facet Ren, Hong-Tao
Li, Yi-Ming
Wang, Xi-Jing
Kang, Hua-Feng
Jin, Tian-Bo
Ma, Xiao-Bin
Liu, Xing-Han
Wang, Meng
Liu, Kang
Xu, Peng
Yao, Qing-Ling
Dai, Zhi-Jun
author_sort Ren, Hong-Tao
collection PubMed
description Programmed death-1 (PD-1) is crucial in cancer and is well characterized as a negative T-cell regulator that functions by delivering inhibitory signals. We aimed to evaluate the relationship between PD-1 polymorphisms (rs10204525, rs2227982, and rs7421861) and breast cancer risk. We selected 560 breast cancer patients and 583 age-, sex-, and ethnicity-matched healthy controls from Northwest China. The PD-1 polymorphisms were genotyped by using Sequenom MassARRAY. Associations were estimated with odds ratios (ORs) and 95% confidence intervals (95% CIs). For the rs10204525 and rs7421861 polymorphisms, no differences in breast cancer risk were found in any of the genetic models. For the rs2227982 polymorphism, the variant genotypes were significantly associated with decreased breast cancer risk (CT vs CC: OR = 0.68, 95% CI = 0.52–0.91; CT + TT vs CC: OR = 0.69, 95% CI = 0.53–0.90). In analyses stratified by age, the decreased risk was observed among the younger subjects (OR = 0.68, 95% CI = 0.47–0.97). We found that the decreased risk observed for the variant genotypes of rs2227982 was associated with the Her-2 status (CT vs CC: OR = 0.55, 95% CI = 0.37–0.84; CT + TT vs CC: OR = 0.56, 95% CI = 0.38–0.82). The haplotype analysis showed that the A(rs10204525) T(rs2227982) C(rs7421861) haplotype was associated with a significantly decreased risk of breast cancer (OR = 0.50, 95% CI = 0.34–0.75). Our findings support an association between the PD-1 rs2227982 polymorphism and decreased breast cancer risk, especially in Her-2 positive breast cancer patients in the Chinese population.
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spelling pubmed-49023682016-06-23 PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study Ren, Hong-Tao Li, Yi-Ming Wang, Xi-Jing Kang, Hua-Feng Jin, Tian-Bo Ma, Xiao-Bin Liu, Xing-Han Wang, Meng Liu, Kang Xu, Peng Yao, Qing-Ling Dai, Zhi-Jun Medicine (Baltimore) 3500 Programmed death-1 (PD-1) is crucial in cancer and is well characterized as a negative T-cell regulator that functions by delivering inhibitory signals. We aimed to evaluate the relationship between PD-1 polymorphisms (rs10204525, rs2227982, and rs7421861) and breast cancer risk. We selected 560 breast cancer patients and 583 age-, sex-, and ethnicity-matched healthy controls from Northwest China. The PD-1 polymorphisms were genotyped by using Sequenom MassARRAY. Associations were estimated with odds ratios (ORs) and 95% confidence intervals (95% CIs). For the rs10204525 and rs7421861 polymorphisms, no differences in breast cancer risk were found in any of the genetic models. For the rs2227982 polymorphism, the variant genotypes were significantly associated with decreased breast cancer risk (CT vs CC: OR = 0.68, 95% CI = 0.52–0.91; CT + TT vs CC: OR = 0.69, 95% CI = 0.53–0.90). In analyses stratified by age, the decreased risk was observed among the younger subjects (OR = 0.68, 95% CI = 0.47–0.97). We found that the decreased risk observed for the variant genotypes of rs2227982 was associated with the Her-2 status (CT vs CC: OR = 0.55, 95% CI = 0.37–0.84; CT + TT vs CC: OR = 0.56, 95% CI = 0.38–0.82). The haplotype analysis showed that the A(rs10204525) T(rs2227982) C(rs7421861) haplotype was associated with a significantly decreased risk of breast cancer (OR = 0.50, 95% CI = 0.34–0.75). Our findings support an association between the PD-1 rs2227982 polymorphism and decreased breast cancer risk, especially in Her-2 positive breast cancer patients in the Chinese population. Wolters Kluwer Health 2016-05-27 /pmc/articles/PMC4902368/ /pubmed/27227944 http://dx.doi.org/10.1097/MD.0000000000003760 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3500
Ren, Hong-Tao
Li, Yi-Ming
Wang, Xi-Jing
Kang, Hua-Feng
Jin, Tian-Bo
Ma, Xiao-Bin
Liu, Xing-Han
Wang, Meng
Liu, Kang
Xu, Peng
Yao, Qing-Ling
Dai, Zhi-Jun
PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study
title PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study
title_full PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study
title_fullStr PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study
title_full_unstemmed PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study
title_short PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study
title_sort pd-1 rs2227982 polymorphism is associated with the decreased risk of breast cancer in northwest chinese women: a hospital-based observational study
topic 3500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902368/
https://www.ncbi.nlm.nih.gov/pubmed/27227944
http://dx.doi.org/10.1097/MD.0000000000003760
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