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Association Between Psoriasis and Subclinical Atherosclerosis: A Meta-Analysis

The association between psoriasis and carotid intima-media thickness (CIMT) or impaired flow-mediated dilation (FMD) remains controversial. We aimed to evaluate the extent of subclinical atherosclerosis as measured by CIMT and FMD in patients with psoriasis by conducting a meta-analysis. A systemati...

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Autores principales: Fang, Na, Jiang, Menglin, Fan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902401/
https://www.ncbi.nlm.nih.gov/pubmed/27196459
http://dx.doi.org/10.1097/MD.0000000000003576
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author Fang, Na
Jiang, Menglin
Fan, Yu
author_facet Fang, Na
Jiang, Menglin
Fan, Yu
author_sort Fang, Na
collection PubMed
description The association between psoriasis and carotid intima-media thickness (CIMT) or impaired flow-mediated dilation (FMD) remains controversial. We aimed to evaluate the extent of subclinical atherosclerosis as measured by CIMT and FMD in patients with psoriasis by conducting a meta-analysis. A systematic literature search was performed using PubMed, Embase, Cochrane databases, China National Knowledge Infrastructure, and VIP databases up to February 2015. Observational studies investigating CIMT or FMD in patients with psoriasis and controls were eligible. Psoriatic patients and controls were at least age- and sex-matched. Random-effects analysis was used to estimate the weighted mean difference (WMD) and 95% confidence interval (CI) between psoriatic patients and controls. A total of 20 studies were identified and analyzed. Meta-analysis showed that psoriatic patients had a significantly thicker CIMT (WMD 0.11 mm; 95% CI 0.08–0.15) and lower FMD (WMD −2.79%; −4.14% to −1.43%) than those in controls. Subgroup analysis indicated that psoriatic arthritis appeared to have less impaired FMD (WMD −2.45%) and thinner CIMT (WMD 0.10 mm). Psoriatic patients with mean age >45 years had much thicker CIMT (WMD 0.13 mm). The impaired FMD (WMD −3.99%) seemed more pronounced in psoriatic patients with mean age <45 years. This meta-analysis suggests that patients with psoriasis are associated with excessive risk of subclinical atherosclerosis. Screening and monitoring CIMT and brachial artery FMD may be recommended to identify a subgroup of psoriatic patients at higher risk for cardiovascular events.
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spelling pubmed-49024012016-06-23 Association Between Psoriasis and Subclinical Atherosclerosis: A Meta-Analysis Fang, Na Jiang, Menglin Fan, Yu Medicine (Baltimore) 4000 The association between psoriasis and carotid intima-media thickness (CIMT) or impaired flow-mediated dilation (FMD) remains controversial. We aimed to evaluate the extent of subclinical atherosclerosis as measured by CIMT and FMD in patients with psoriasis by conducting a meta-analysis. A systematic literature search was performed using PubMed, Embase, Cochrane databases, China National Knowledge Infrastructure, and VIP databases up to February 2015. Observational studies investigating CIMT or FMD in patients with psoriasis and controls were eligible. Psoriatic patients and controls were at least age- and sex-matched. Random-effects analysis was used to estimate the weighted mean difference (WMD) and 95% confidence interval (CI) between psoriatic patients and controls. A total of 20 studies were identified and analyzed. Meta-analysis showed that psoriatic patients had a significantly thicker CIMT (WMD 0.11 mm; 95% CI 0.08–0.15) and lower FMD (WMD −2.79%; −4.14% to −1.43%) than those in controls. Subgroup analysis indicated that psoriatic arthritis appeared to have less impaired FMD (WMD −2.45%) and thinner CIMT (WMD 0.10 mm). Psoriatic patients with mean age >45 years had much thicker CIMT (WMD 0.13 mm). The impaired FMD (WMD −3.99%) seemed more pronounced in psoriatic patients with mean age <45 years. This meta-analysis suggests that patients with psoriasis are associated with excessive risk of subclinical atherosclerosis. Screening and monitoring CIMT and brachial artery FMD may be recommended to identify a subgroup of psoriatic patients at higher risk for cardiovascular events. Wolters Kluwer Health 2016-05-20 /pmc/articles/PMC4902401/ /pubmed/27196459 http://dx.doi.org/10.1097/MD.0000000000003576 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4000
Fang, Na
Jiang, Menglin
Fan, Yu
Association Between Psoriasis and Subclinical Atherosclerosis: A Meta-Analysis
title Association Between Psoriasis and Subclinical Atherosclerosis: A Meta-Analysis
title_full Association Between Psoriasis and Subclinical Atherosclerosis: A Meta-Analysis
title_fullStr Association Between Psoriasis and Subclinical Atherosclerosis: A Meta-Analysis
title_full_unstemmed Association Between Psoriasis and Subclinical Atherosclerosis: A Meta-Analysis
title_short Association Between Psoriasis and Subclinical Atherosclerosis: A Meta-Analysis
title_sort association between psoriasis and subclinical atherosclerosis: a meta-analysis
topic 4000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902401/
https://www.ncbi.nlm.nih.gov/pubmed/27196459
http://dx.doi.org/10.1097/MD.0000000000003576
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