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Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials

Osteoarthritis (OA) is the most common form of arthritis in older individuals and is among the most prevalent and disabling chronic conditions worldwide. We conducted a meta-analysis to determine the efficacy and safety of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor in the treatment of osteoarth...

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Autores principales: Xu, Chao, Gu, Ke, Yasen, Yalikun, Hou, Yanjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902402/
https://www.ncbi.nlm.nih.gov/pubmed/27196460
http://dx.doi.org/10.1097/MD.0000000000003585
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author Xu, Chao
Gu, Ke
Yasen, Yalikun
Hou, Yanjie
author_facet Xu, Chao
Gu, Ke
Yasen, Yalikun
Hou, Yanjie
author_sort Xu, Chao
collection PubMed
description Osteoarthritis (OA) is the most common form of arthritis in older individuals and is among the most prevalent and disabling chronic conditions worldwide. We conducted a meta-analysis to determine the efficacy and safety of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor in the treatment of osteoarthritis. Studies were pooled, and mean difference (MD), relative risk (RR), and its corresponding 95% confidence interval (CI) were calculated. Fifteen relevant articles were included for this meta-analysis study. We observed that osteoarthritis total score (MD = −4.41, 95% CI −7.27 to −1.55), pain subscale score (MD = −0.86, 95% CI −1.10 to −0.62), and function subscale score (MD = −2.90, 95% CI −5.12 to −0.67) in OA patients treatment with celecoxib was significantly improved than that with placebo. There was no significant difference in the incidence of adverse events (AEs), SAEs, and discontinuations due to AEs; however, the incidence of gastrointestinal AEs in OA patients treatment with celecoxib is significantly higher than that with placebo. For AE, the incidence of abdominal pain in OA patients with celecoxib was significantly higher than that with placebo (RR = 2.24, 95% CI: 1.40–3.58; P = 0.839, I(2) = 0%). There was no significant difference in diarrhea, dyspepsia, headache, and nausea. This meta-analysis indicated that celecoxib treatment (200 mg orally once daily) led to significant improvement in the pain and function of osteoarthritis. However, compared with placebo control, celecoxib resulted in greater gastrointestinal AEs, especially abdominal pain after approximately 10 to 13 weeks of treatment. The current study, therefore, provides valuable information to help physicians make treatment decisions for their patients with OA.
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spelling pubmed-49024022016-06-23 Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials Xu, Chao Gu, Ke Yasen, Yalikun Hou, Yanjie Medicine (Baltimore) 7100 Osteoarthritis (OA) is the most common form of arthritis in older individuals and is among the most prevalent and disabling chronic conditions worldwide. We conducted a meta-analysis to determine the efficacy and safety of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor in the treatment of osteoarthritis. Studies were pooled, and mean difference (MD), relative risk (RR), and its corresponding 95% confidence interval (CI) were calculated. Fifteen relevant articles were included for this meta-analysis study. We observed that osteoarthritis total score (MD = −4.41, 95% CI −7.27 to −1.55), pain subscale score (MD = −0.86, 95% CI −1.10 to −0.62), and function subscale score (MD = −2.90, 95% CI −5.12 to −0.67) in OA patients treatment with celecoxib was significantly improved than that with placebo. There was no significant difference in the incidence of adverse events (AEs), SAEs, and discontinuations due to AEs; however, the incidence of gastrointestinal AEs in OA patients treatment with celecoxib is significantly higher than that with placebo. For AE, the incidence of abdominal pain in OA patients with celecoxib was significantly higher than that with placebo (RR = 2.24, 95% CI: 1.40–3.58; P = 0.839, I(2) = 0%). There was no significant difference in diarrhea, dyspepsia, headache, and nausea. This meta-analysis indicated that celecoxib treatment (200 mg orally once daily) led to significant improvement in the pain and function of osteoarthritis. However, compared with placebo control, celecoxib resulted in greater gastrointestinal AEs, especially abdominal pain after approximately 10 to 13 weeks of treatment. The current study, therefore, provides valuable information to help physicians make treatment decisions for their patients with OA. Wolters Kluwer Health 2016-05-20 /pmc/articles/PMC4902402/ /pubmed/27196460 http://dx.doi.org/10.1097/MD.0000000000003585 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 7100
Xu, Chao
Gu, Ke
Yasen, Yalikun
Hou, Yanjie
Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials
title Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials
title_full Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials
title_fullStr Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials
title_short Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials
title_sort efficacy and safety of celecoxib therapy in osteoarthritis: a meta-analysis of randomized controlled trials
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902402/
https://www.ncbi.nlm.nih.gov/pubmed/27196460
http://dx.doi.org/10.1097/MD.0000000000003585
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