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Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma

Non-small-cell lung cancer (NSCLC) is a lethal and aggressive malignancy. Currently, the identities of prognostic and predictive makers of NSCLC have not been fully established. Dysregulated Notch signaling has been implicated in many human malignancies, including NSCLC. However, the prognostic valu...

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Autores principales: Liu, Zhi-Yan, Wu, Tao, Li, Qing, Wang, Min-Cong, Jing, Li, Ruan, Zhi-Ping, Yao, Yu, Nan, Ke-Jun, Guo, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902431/
https://www.ncbi.nlm.nih.gov/pubmed/27196489
http://dx.doi.org/10.1097/MD.0000000000003715
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author Liu, Zhi-Yan
Wu, Tao
Li, Qing
Wang, Min-Cong
Jing, Li
Ruan, Zhi-Ping
Yao, Yu
Nan, Ke-Jun
Guo, Hui
author_facet Liu, Zhi-Yan
Wu, Tao
Li, Qing
Wang, Min-Cong
Jing, Li
Ruan, Zhi-Ping
Yao, Yu
Nan, Ke-Jun
Guo, Hui
author_sort Liu, Zhi-Yan
collection PubMed
description Non-small-cell lung cancer (NSCLC) is a lethal and aggressive malignancy. Currently, the identities of prognostic and predictive makers of NSCLC have not been fully established. Dysregulated Notch signaling has been implicated in many human malignancies, including NSCLC. However, the prognostic value of measuring Notch signaling and the utility of developing Notch-targeted therapies in NSCLC remain inconclusive. The present study investigated the association of individual Notch receptor and ligand levels with lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) prognosis using the Kaplan-Meier plotte database. This online database encompasses 2437 lung cancer samples. Hazard ratios with 95% confidence intervals were calculated. The results showed that higher Notch1, Notch2, JAG1, and DLL1 mRNA expression predicted better overall survival (OS) in lung ADC, but showed no significance in SCC patients. Elevated Notch3, JAG2, and DLL3 mRNA expression was associated with poor OS of ADC patients, but not in SCC patients. There was no association between Notch4 and OS in either lung ADC or SCC patients. In conclusion, the set of Notch1, Notch2, JAG1, DLL1 and that of Notch3, JAG2, DLL3 played opposing prognostic roles in lung ADC patients. Neither set of Notch receptors and ligands was indicative of lung SCC prognosis. Notch signaling could serve as promising marker to predict outcomes in lung ADC patients. The distinct features of lung cancer subtypes and Notch components should be considered when developing future Notch-targeted therapies.
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spelling pubmed-49024312016-06-23 Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma Liu, Zhi-Yan Wu, Tao Li, Qing Wang, Min-Cong Jing, Li Ruan, Zhi-Ping Yao, Yu Nan, Ke-Jun Guo, Hui Medicine (Baltimore) 5700 Non-small-cell lung cancer (NSCLC) is a lethal and aggressive malignancy. Currently, the identities of prognostic and predictive makers of NSCLC have not been fully established. Dysregulated Notch signaling has been implicated in many human malignancies, including NSCLC. However, the prognostic value of measuring Notch signaling and the utility of developing Notch-targeted therapies in NSCLC remain inconclusive. The present study investigated the association of individual Notch receptor and ligand levels with lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) prognosis using the Kaplan-Meier plotte database. This online database encompasses 2437 lung cancer samples. Hazard ratios with 95% confidence intervals were calculated. The results showed that higher Notch1, Notch2, JAG1, and DLL1 mRNA expression predicted better overall survival (OS) in lung ADC, but showed no significance in SCC patients. Elevated Notch3, JAG2, and DLL3 mRNA expression was associated with poor OS of ADC patients, but not in SCC patients. There was no association between Notch4 and OS in either lung ADC or SCC patients. In conclusion, the set of Notch1, Notch2, JAG1, DLL1 and that of Notch3, JAG2, DLL3 played opposing prognostic roles in lung ADC patients. Neither set of Notch receptors and ligands was indicative of lung SCC prognosis. Notch signaling could serve as promising marker to predict outcomes in lung ADC patients. The distinct features of lung cancer subtypes and Notch components should be considered when developing future Notch-targeted therapies. Wolters Kluwer Health 2016-05-20 /pmc/articles/PMC4902431/ /pubmed/27196489 http://dx.doi.org/10.1097/MD.0000000000003715 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5700
Liu, Zhi-Yan
Wu, Tao
Li, Qing
Wang, Min-Cong
Jing, Li
Ruan, Zhi-Ping
Yao, Yu
Nan, Ke-Jun
Guo, Hui
Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma
title Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma
title_full Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma
title_fullStr Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma
title_full_unstemmed Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma
title_short Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma
title_sort notch signaling components: diverging prognostic indicators in lung adenocarcinoma
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902431/
https://www.ncbi.nlm.nih.gov/pubmed/27196489
http://dx.doi.org/10.1097/MD.0000000000003715
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