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The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis

Multiple sclerosis (MS) is the most frequent nontraumatic disabling neurological disease among young adults. Previous studies have examined the association of rs703842 in CYP27B1 with MS susceptibility, with inconsistent results reported. The objective of this study is to conduct a systematic litera...

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Autores principales: Jiang, Tao, Li, Lizhuo, Wang, Ying, Zhao, Chuntao, Yang, Jundong, Ma, Dexuan, Guan, Yanlei, Zhao, Dan, Bao, Yijun, Wang, Yunjie, Yang, Jingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902511/
https://www.ncbi.nlm.nih.gov/pubmed/27175669
http://dx.doi.org/10.1097/MD.0000000000003612
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author Jiang, Tao
Li, Lizhuo
Wang, Ying
Zhao, Chuntao
Yang, Jundong
Ma, Dexuan
Guan, Yanlei
Zhao, Dan
Bao, Yijun
Wang, Yunjie
Yang, Jingyun
author_facet Jiang, Tao
Li, Lizhuo
Wang, Ying
Zhao, Chuntao
Yang, Jundong
Ma, Dexuan
Guan, Yanlei
Zhao, Dan
Bao, Yijun
Wang, Yunjie
Yang, Jingyun
author_sort Jiang, Tao
collection PubMed
description Multiple sclerosis (MS) is the most frequent nontraumatic disabling neurological disease among young adults. Previous studies have examined the association of rs703842 in CYP27B1 with MS susceptibility, with inconsistent results reported. The objective of this study is to conduct a systematic literature search and perform meta-analyses to examine whether rs703842 is associated with MS risk. We searched potential literature in PubMed, Cochrane Library, Embase, Google Scholar, Web of Science, and HuGE by using the following inclusion criteria: studies were on human subjects; the studies were case–control studies; studies included subjects who had MS and those who did not have MS; and the studies provided genotype data for rs703842 for subjects who had and did not have MS, or provided odds ratios (ORs) and the 95% confidence intervals (CIs) for assessing the association of rs703842 with MS, or provided sufficient data for the calculation of OR and the 95% CI. We used random-effects models to calculate the OR as a measure of association. We used I(2) to assess between-study heterogeneity, and a funnel plot and Egger test to assess publication bias. Seven studies published since 2008 met the eligibility criteria and were included in the meta-analyses. We found that the C allele was significantly associated with reduced MS susceptibility (OR = 0.88, 95% CI: 0.80–0.89; P < 0.0001). We also found significant association of rs703842 with MS risk using a dominant and a recessive model (both P < 0.0002). Our results remain unchanged if our meta-analysis was limited to studies that included only Caucasian participants (OR = 0.85, 95% CI: 0.80–0.90; P < 0.0001). Our study has several limitations: The sample size is limited; We were unable to control for some important confounding factors as data for individual participant were not available; and Most of the included studies focus on MS risk in Caucasian. As a result, we could not perform meta-analysis for assessing the relationship in other ethnic groups. In summary, we found that the genetic variant rs703842 in CYP27B1 is associated with MS risk in Caucasians. More studies with larger sample size that control for important confounding factors are needed to validate the findings from this study.
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spelling pubmed-49025112016-06-27 The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis Jiang, Tao Li, Lizhuo Wang, Ying Zhao, Chuntao Yang, Jundong Ma, Dexuan Guan, Yanlei Zhao, Dan Bao, Yijun Wang, Yunjie Yang, Jingyun Medicine (Baltimore) 5300 Multiple sclerosis (MS) is the most frequent nontraumatic disabling neurological disease among young adults. Previous studies have examined the association of rs703842 in CYP27B1 with MS susceptibility, with inconsistent results reported. The objective of this study is to conduct a systematic literature search and perform meta-analyses to examine whether rs703842 is associated with MS risk. We searched potential literature in PubMed, Cochrane Library, Embase, Google Scholar, Web of Science, and HuGE by using the following inclusion criteria: studies were on human subjects; the studies were case–control studies; studies included subjects who had MS and those who did not have MS; and the studies provided genotype data for rs703842 for subjects who had and did not have MS, or provided odds ratios (ORs) and the 95% confidence intervals (CIs) for assessing the association of rs703842 with MS, or provided sufficient data for the calculation of OR and the 95% CI. We used random-effects models to calculate the OR as a measure of association. We used I(2) to assess between-study heterogeneity, and a funnel plot and Egger test to assess publication bias. Seven studies published since 2008 met the eligibility criteria and were included in the meta-analyses. We found that the C allele was significantly associated with reduced MS susceptibility (OR = 0.88, 95% CI: 0.80–0.89; P < 0.0001). We also found significant association of rs703842 with MS risk using a dominant and a recessive model (both P < 0.0002). Our results remain unchanged if our meta-analysis was limited to studies that included only Caucasian participants (OR = 0.85, 95% CI: 0.80–0.90; P < 0.0001). Our study has several limitations: The sample size is limited; We were unable to control for some important confounding factors as data for individual participant were not available; and Most of the included studies focus on MS risk in Caucasian. As a result, we could not perform meta-analysis for assessing the relationship in other ethnic groups. In summary, we found that the genetic variant rs703842 in CYP27B1 is associated with MS risk in Caucasians. More studies with larger sample size that control for important confounding factors are needed to validate the findings from this study. Wolters Kluwer Health 2016-05-13 /pmc/articles/PMC4902511/ /pubmed/27175669 http://dx.doi.org/10.1097/MD.0000000000003612 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5300
Jiang, Tao
Li, Lizhuo
Wang, Ying
Zhao, Chuntao
Yang, Jundong
Ma, Dexuan
Guan, Yanlei
Zhao, Dan
Bao, Yijun
Wang, Yunjie
Yang, Jingyun
The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis
title The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis
title_full The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis
title_fullStr The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis
title_full_unstemmed The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis
title_short The Association Between Genetic Polymorphism rs703842 in CYP27B1 and Multiple Sclerosis: A Meta-Analysis
title_sort association between genetic polymorphism rs703842 in cyp27b1 and multiple sclerosis: a meta-analysis
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902511/
https://www.ncbi.nlm.nih.gov/pubmed/27175669
http://dx.doi.org/10.1097/MD.0000000000003612
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