Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse

BACKGROUND: A characteristic phenotype of congenital generalized lipodystrophy 2 (CGL2) that is caused by loss-of-function of seipin gene is mental retardation. Seipin is highly expressed in hippocampal pyramidal cells and astrocytes. Neuronal knockout of seipin in mice (seipin-KO mice) reduces the...

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Detalles Bibliográficos
Autores principales: Qian, Yun, Yin, Jun, Hong, Juan, Li, Guoxi, Zhang, Baofeng, Liu, George, Wan, Qi, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902906/
https://www.ncbi.nlm.nih.gov/pubmed/27287266
http://dx.doi.org/10.1186/s12974-016-0598-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902906/
https://www.ncbi.nlm.nih.gov/pubmed/27287266
http://dx.doi.org/10.1186/s12974-016-0598-3

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