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Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse

BACKGROUND: A characteristic phenotype of congenital generalized lipodystrophy 2 (CGL2) that is caused by loss-of-function of seipin gene is mental retardation. Seipin is highly expressed in hippocampal pyramidal cells and astrocytes. Neuronal knockout of seipin in mice (seipin-KO mice) reduces the...

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Detalles Bibliográficos
Autores principales:	Qian, Yun, Yin, Jun, Hong, Juan, Li, Guoxi, Zhang, Baofeng, Liu, George, Wan, Qi, Chen, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902906/ https://www.ncbi.nlm.nih.gov/pubmed/27287266 http://dx.doi.org/10.1186/s12974-016-0598-3

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