Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

BACKGROUND: Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer’s disease. However, the function of OSM in these disease conditions is unclear. Since deficient glutamate uptake by astrocy...

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Detalles Bibliográficos
Autores principales: Moidunny, Shamsudheen, Matos, Marco, Wesseling, Evelyn, Banerjee, Santanu, Volsky, David J., Cunha, Rodrigo A., Agostinho, Paula, Boddeke, Hendrikus W., Roy, Sabita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903004/
https://www.ncbi.nlm.nih.gov/pubmed/27287400
http://dx.doi.org/10.1186/s12974-016-0613-8

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