Cargando…

Biological subtyping of early breast cancer: a study comparing RT-qPCR with immunohistochemistry

The biological subtype of breast cancer influences the selection of systemic therapy. Distinction between luminal A and B cancers depends on consistent assessment of Ki-67, but substantial intra-observer and inter-observer variability exists when immunohistochemistry (IHC) is used. We compared RT-qP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wirtz, Ralph M., Sihto, Harri, Isola, Jorma, Heikkilä, Päivi, Kellokumpu-Lehtinen, Pirkko-Liisa, Auvinen, Päivi, Turpeenniemi-Hujanen, Taina, Jyrkkiö, Sirkku, Lakis, Sotiris, Schlombs, Kornelia, Laible, Mark, Weber, Stefan, Eidt, Sebastian, Sahin, Ugur, Joensuu, Heikki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2016
Materias:	Preclinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903103/ https://www.ncbi.nlm.nih.gov/pubmed/27220750 http://dx.doi.org/10.1007/s10549-016-3835-7

Ejemplares similares

Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study
por: Sihto, Harri, et al.
Publicado: (2011)

Comparison of immunohistochemistry with PCR for assessment of ER, PR, and Ki-67 and prediction of pathological complete response in breast cancer
por: Sinn, Hans-Peter, et al.
Publicado: (2017)

Technical validation of an RT-qPCR in vitro diagnostic test system for the determination of breast cancer molecular subtypes by quantification of ERBB2, ESR1, PGR and MKI67 mRNA levels from formalin-fixed paraffin-embedded breast tumor specimens
por: Laible, Mark, et al.
Publicado: (2016)

Long-term prognosis of breast cancer detected by mammography screening or other methods
por: Lehtimäki, Tiina, et al.
Publicado: (2011)

Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer
por: Konsti, Juho, et al.
Publicado: (2011)

Clever-1 positive macrophages in breast cancer
por: Mutka, Minna, et al.
Publicado: (2022)

The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype
por: Tiainen, Satu, et al.
Publicado: (2020)

Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy
por: Bychkov, Dmitrii, et al.
Publicado: (2021)

Outcome and biomarker supervised deep learning for survival prediction in two multicenter breast cancer series
por: Bychkov, Dmitrii, et al.
Publicado: (2022)

Levels of Circulating TIMP-2 and MMP2-TIMP2 Complex Are Decreased in Squamous Cervical Carcinoma
por: Anne, Talvensaari-Mattila, et al.
Publicado: (2010)

Predictive value of molecular subtyping in NMIBC by RT-qPCR of ERBB2, ESR1, PGR and MKI67 from formalin fixed TUR biopsies
por: Breyer, Johannes, et al.
Publicado: (2017)

Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis
por: Tiainen, Satu, et al.
Publicado: (2019)

The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer
por: Jääskeläinen, Minna M., et al.
Publicado: (2023)

Docetaxel versus docetaxel alternating with gemcitabine as treatments of advanced breast cancer: final analysis of a randomised trial
por: Joensuu, H., et al.
Publicado: (2010)

The Sample Type used Affects the Levels of Gelatinases (MMP-2 and -9) and their Inhibitors (TIMP-1 and -2) in Circulating Blood of Healthy Controls and Breast Cancer Patients
por: Paula, Kuvaja, et al.
Publicado: (2007)

Adjuvant Capecitabine for Early Breast Cancer: 15-Year Overall Survival Results From a Randomized Trial
por: Joensuu, Heikki, et al.
Publicado: (2022)

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription
por: Kaukonen, Riina, et al.
Publicado: (2016)

Significance of bulky mass and residual tumor—Treated with or without consolidative radiotherapy—To the risk of relapse in DLBCL patients
por: Tokola, Susanna, et al.
Publicado: (2020)

Interim and end‐of‐treatment PET‐CT suffers from high false‐positive rates in DLBCL: Biopsy is needed prior to treatment decisions
por: Tokola, Susanna, et al.
Publicado: (2021)

Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer
por: Sihto, Harri, et al.
Publicado: (2012)

Outcome of patients with HER2-positive breast cancer treated with or without adjuvant trastuzumab in the Finland Capecitabine Trial (FinXX)
por: Joensuu, Heikki, et al.
Publicado: (2014)

Breast cancer outcome prediction with tumour tissue images and machine learning
por: Turkki, Riku, et al.
Publicado: (2019)

Discordance between PAM50 intrinsic subtyping and immunohistochemistry in South African women with breast cancer
por: Dix-Peek, Thérèse, et al.
Publicado: (2023)

3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography
por: Tuohinen, Suvi Sirkku, et al.
Publicado: (2021)

p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression.
por: Soini, Y., et al.
Publicado: (1993)

The past and present of prostate cancer and its treatment and diagnostics: A historical review
por: Lehtonen, Miikka, et al.
Publicado: (2023)

Breast cancer subtyping by immunohistochemistry and histological grade outperforms breast cancer intrinsic subtypes in predicting neoadjuvant chemotherapy response
por: Lips, E. H., et al.
Publicado: (2013)

ERBB4 Promoter Polymorphism Is Associated with Poor Distant Disease-Free Survival in High-Risk Early Breast Cancer
por: Kurppa, Kari J., et al.
Publicado: (2014)

Robustness of biomarker determination in breast cancer by RT-qPCR: impact of tumor cell content, DCIS and non-neoplastic breast tissue
por: Hartmann, Kerstin, et al.
Publicado: (2018)

Quantities of CD3+, CD8+ and CD56+ lymphocytes decline in breast cancer recurrences while CD4+ remain similar
por: Mutka, Minna, et al.
Publicado: (2023)

Transient Changes in Serum CEA, CA19-9, CRP, YKL-40, and IL-6 during Adjuvant Chemotherapy and Survival of Patients with Colorectal Cancer
por: Lehtomäki, Kaisa, et al.
Publicado: (2023)

Combination of Strong MMP-2 and Weak TIMP-2 Immunostainings Is a Significant Prognostic Factor in Endometrial Carcinoma
por: Honkavuori-Toivola, Maria, et al.
Publicado: (2013)

Immunohistochemistry and fluorescence in situ hybridization assessment of HER2 in clinical trials of adjuvant therapy for breast cancer (NCCTG N9831, BCIRG 006, and BCIRG 005)
por: Perez, Edith A., et al.
Publicado: (2013)

LINE-1 hypomethylation in familial and sporadic cancer
por: Pavicic, Walter, et al.
Publicado: (2012)

Lead Time and Prognostic Role of Serum CEA, CA19-9, IL-6, CRP, and YKL-40 after Adjuvant Chemotherapy in Colorectal Cancer
por: Lehtomäki, Kaisa, et al.
Publicado: (2021)

p53 in head and neck cancer: Functional consequences and environmental implications of TP53 mutations
por: Peltonen, Jenni K, et al.
Publicado: (2010)

Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure
por: Nissi, Ritva, et al.
Publicado: (2013)

Core needle biopsies alter the amounts of CCR5, Siglec-15, and PD-L1 positivities in breast carcinoma
por: Mutka, Minna, et al.
Publicado: (2023)

Undergraduate curriculum in palliative medicine at Tampere University increases students’ knowledge
por: Lehto, Juho T., et al.
Publicado: (2017)

Both comorbidity and worse performance status are associated with poorer overall survival after external beam radiotherapy for prostate cancer
por: Lehtonen, Miikka, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_43e9orv3msc6il7qffnvo6bpci