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TIM-3 Regulates Distinct Functions in Macrophages
The transmembrane protein TIM-3 is a type I protein expressed by sub-types of lymphoid cells, such as lymphocytes Th1, Th17, Tc1, NK, as well as in myeloid cells. Scientific evidence indicates that this molecule acts as a negative regulator of T lymphocyte activation and that its expression is modif...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904032/ https://www.ncbi.nlm.nih.gov/pubmed/27379093 http://dx.doi.org/10.3389/fimmu.2016.00229 |
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author | Ocaña-Guzman, Ranferi Torre-Bouscoulet, Luis Sada-Ovalle, Isabel |
author_facet | Ocaña-Guzman, Ranferi Torre-Bouscoulet, Luis Sada-Ovalle, Isabel |
author_sort | Ocaña-Guzman, Ranferi |
collection | PubMed |
description | The transmembrane protein TIM-3 is a type I protein expressed by sub-types of lymphoid cells, such as lymphocytes Th1, Th17, Tc1, NK, as well as in myeloid cells. Scientific evidence indicates that this molecule acts as a negative regulator of T lymphocyte activation and that its expression is modified in viral infections or autoimmune diseases. In addition to evidence from lymphoid cells, the function of TIM-3 has been investigated in myeloid cells, such as monocytes, macrophages, and dendritic cells (DC), where studies have demonstrated that it can regulate cytokine production, cell activation, and the capture of apoptotic bodies. Despite these advances, the function of TIM-3 in myeloid cells and the molecular mechanisms that this protein regulates are not yet fully understood. This review examines the most recent evidence concerning the function of TIM-3 when expressed in myeloid cells, primarily macrophages, and the potential impact of that function on the field of basic immunology. |
format | Online Article Text |
id | pubmed-4904032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49040322016-07-04 TIM-3 Regulates Distinct Functions in Macrophages Ocaña-Guzman, Ranferi Torre-Bouscoulet, Luis Sada-Ovalle, Isabel Front Immunol Immunology The transmembrane protein TIM-3 is a type I protein expressed by sub-types of lymphoid cells, such as lymphocytes Th1, Th17, Tc1, NK, as well as in myeloid cells. Scientific evidence indicates that this molecule acts as a negative regulator of T lymphocyte activation and that its expression is modified in viral infections or autoimmune diseases. In addition to evidence from lymphoid cells, the function of TIM-3 has been investigated in myeloid cells, such as monocytes, macrophages, and dendritic cells (DC), where studies have demonstrated that it can regulate cytokine production, cell activation, and the capture of apoptotic bodies. Despite these advances, the function of TIM-3 in myeloid cells and the molecular mechanisms that this protein regulates are not yet fully understood. This review examines the most recent evidence concerning the function of TIM-3 when expressed in myeloid cells, primarily macrophages, and the potential impact of that function on the field of basic immunology. Frontiers Media S.A. 2016-06-13 /pmc/articles/PMC4904032/ /pubmed/27379093 http://dx.doi.org/10.3389/fimmu.2016.00229 Text en Copyright © 2016 Ocaña-Guzman, Torre-Bouscoulet and Sada-Ovalle. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ocaña-Guzman, Ranferi Torre-Bouscoulet, Luis Sada-Ovalle, Isabel TIM-3 Regulates Distinct Functions in Macrophages |
title | TIM-3 Regulates Distinct Functions in Macrophages |
title_full | TIM-3 Regulates Distinct Functions in Macrophages |
title_fullStr | TIM-3 Regulates Distinct Functions in Macrophages |
title_full_unstemmed | TIM-3 Regulates Distinct Functions in Macrophages |
title_short | TIM-3 Regulates Distinct Functions in Macrophages |
title_sort | tim-3 regulates distinct functions in macrophages |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904032/ https://www.ncbi.nlm.nih.gov/pubmed/27379093 http://dx.doi.org/10.3389/fimmu.2016.00229 |
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