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Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives
Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's di...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904074/ https://www.ncbi.nlm.nih.gov/pubmed/27313396 http://dx.doi.org/10.1155/2016/7576292 |
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author | de Tommaso, Marina Arendt-Nielsen, Lars Defrin, Ruth Kunz, Miriam Pickering, Gisele Valeriani, Massimiliano |
author_facet | de Tommaso, Marina Arendt-Nielsen, Lars Defrin, Ruth Kunz, Miriam Pickering, Gisele Valeriani, Massimiliano |
author_sort | de Tommaso, Marina |
collection | PubMed |
description | Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. Many of these patients complain of painful symptoms though their origin is variable, and their presence is frequently not considered in the treatment guidelines, leaving their management to the decision of the clinicians alone. However, studies focusing on pain frequency in such disorders suggest a high prevalence of pain in selected populations from 38 to 75% in AD, 40% to 86% in PD, and 19 to 85% in MND. The methods of pain assessment vary between studies so the type of pain has been rarely reported. However, a prevalent nonneuropathic origin of pain emerged for MND and PD. In AD, no data on pain features are available. No controlled therapeutic trials and guidelines are currently available. Given the relevance of pain in neurodegenerative disorders, the comprehensive understanding of mechanisms and predisposing factors, the application and validation of specific scales, and new specific therapeutic trials are needed. |
format | Online Article Text |
id | pubmed-4904074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49040742016-06-16 Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives de Tommaso, Marina Arendt-Nielsen, Lars Defrin, Ruth Kunz, Miriam Pickering, Gisele Valeriani, Massimiliano Behav Neurol Review Article Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. Many of these patients complain of painful symptoms though their origin is variable, and their presence is frequently not considered in the treatment guidelines, leaving their management to the decision of the clinicians alone. However, studies focusing on pain frequency in such disorders suggest a high prevalence of pain in selected populations from 38 to 75% in AD, 40% to 86% in PD, and 19 to 85% in MND. The methods of pain assessment vary between studies so the type of pain has been rarely reported. However, a prevalent nonneuropathic origin of pain emerged for MND and PD. In AD, no data on pain features are available. No controlled therapeutic trials and guidelines are currently available. Given the relevance of pain in neurodegenerative disorders, the comprehensive understanding of mechanisms and predisposing factors, the application and validation of specific scales, and new specific therapeutic trials are needed. Hindawi Publishing Corporation 2016 2016-06-05 /pmc/articles/PMC4904074/ /pubmed/27313396 http://dx.doi.org/10.1155/2016/7576292 Text en Copyright © 2016 Marina de Tommaso et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article de Tommaso, Marina Arendt-Nielsen, Lars Defrin, Ruth Kunz, Miriam Pickering, Gisele Valeriani, Massimiliano Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
title | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
title_full | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
title_fullStr | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
title_full_unstemmed | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
title_short | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
title_sort | pain in neurodegenerative disease: current knowledge and future perspectives |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904074/ https://www.ncbi.nlm.nih.gov/pubmed/27313396 http://dx.doi.org/10.1155/2016/7576292 |
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