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Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives

Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's di...

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Autores principales: de Tommaso, Marina, Arendt-Nielsen, Lars, Defrin, Ruth, Kunz, Miriam, Pickering, Gisele, Valeriani, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904074/
https://www.ncbi.nlm.nih.gov/pubmed/27313396
http://dx.doi.org/10.1155/2016/7576292
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author de Tommaso, Marina
Arendt-Nielsen, Lars
Defrin, Ruth
Kunz, Miriam
Pickering, Gisele
Valeriani, Massimiliano
author_facet de Tommaso, Marina
Arendt-Nielsen, Lars
Defrin, Ruth
Kunz, Miriam
Pickering, Gisele
Valeriani, Massimiliano
author_sort de Tommaso, Marina
collection PubMed
description Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. Many of these patients complain of painful symptoms though their origin is variable, and their presence is frequently not considered in the treatment guidelines, leaving their management to the decision of the clinicians alone. However, studies focusing on pain frequency in such disorders suggest a high prevalence of pain in selected populations from 38 to 75% in AD, 40% to 86% in PD, and 19 to 85% in MND. The methods of pain assessment vary between studies so the type of pain has been rarely reported. However, a prevalent nonneuropathic origin of pain emerged for MND and PD. In AD, no data on pain features are available. No controlled therapeutic trials and guidelines are currently available. Given the relevance of pain in neurodegenerative disorders, the comprehensive understanding of mechanisms and predisposing factors, the application and validation of specific scales, and new specific therapeutic trials are needed.
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spelling pubmed-49040742016-06-16 Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives de Tommaso, Marina Arendt-Nielsen, Lars Defrin, Ruth Kunz, Miriam Pickering, Gisele Valeriani, Massimiliano Behav Neurol Review Article Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. Many of these patients complain of painful symptoms though their origin is variable, and their presence is frequently not considered in the treatment guidelines, leaving their management to the decision of the clinicians alone. However, studies focusing on pain frequency in such disorders suggest a high prevalence of pain in selected populations from 38 to 75% in AD, 40% to 86% in PD, and 19 to 85% in MND. The methods of pain assessment vary between studies so the type of pain has been rarely reported. However, a prevalent nonneuropathic origin of pain emerged for MND and PD. In AD, no data on pain features are available. No controlled therapeutic trials and guidelines are currently available. Given the relevance of pain in neurodegenerative disorders, the comprehensive understanding of mechanisms and predisposing factors, the application and validation of specific scales, and new specific therapeutic trials are needed. Hindawi Publishing Corporation 2016 2016-06-05 /pmc/articles/PMC4904074/ /pubmed/27313396 http://dx.doi.org/10.1155/2016/7576292 Text en Copyright © 2016 Marina de Tommaso et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
de Tommaso, Marina
Arendt-Nielsen, Lars
Defrin, Ruth
Kunz, Miriam
Pickering, Gisele
Valeriani, Massimiliano
Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives
title Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives
title_full Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives
title_fullStr Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives
title_full_unstemmed Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives
title_short Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives
title_sort pain in neurodegenerative disease: current knowledge and future perspectives
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904074/
https://www.ncbi.nlm.nih.gov/pubmed/27313396
http://dx.doi.org/10.1155/2016/7576292
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