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Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. Currently, there are no recognized medical therapies effective for NAFLD. Previous studies have demonstrated the effects of total turmeric extract on rats with NAFLD induced by high-fat diet. In this s...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904104/ https://www.ncbi.nlm.nih.gov/pubmed/27366193 http://dx.doi.org/10.1155/2016/8495953 |
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author | Wang, Ya Niu, Ming Jia, Ge-liu-chang Li, Rui-sheng Zhang, Ya-ming Zhang, Cong-en Meng, Ya-kun Cui, He-rong Ma, Zhi-jie Li, Dong-hui Wang, Jia-bo Xiao, Xiao-he |
author_facet | Wang, Ya Niu, Ming Jia, Ge-liu-chang Li, Rui-sheng Zhang, Ya-ming Zhang, Cong-en Meng, Ya-kun Cui, He-rong Ma, Zhi-jie Li, Dong-hui Wang, Jia-bo Xiao, Xiao-he |
author_sort | Wang, Ya |
collection | PubMed |
description | Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. Currently, there are no recognized medical therapies effective for NAFLD. Previous studies have demonstrated the effects of total turmeric extract on rats with NAFLD induced by high-fat diet. In this study, serum metabolomics was employed using UHPLC-Q-TOF-MS to elucidate the underlying mechanisms of HFD-induced NAFLD and the therapeutic effects of TE. Supervised orthogonal partial least-squares-discriminant analysis was used to discover differentiating metabolites, and pathway enrichment analysis suggested that TE had powerful combined effects of regulating lipid metabolism by affecting glycerophospholipid metabolism, glycerolipid metabolism, and steroid hormone biosynthesis signaling pathways. In addition, the significant changes in glycerophospholipid metabolism proteins also indicated that glycerophospholipid metabolism might be involved in the therapeutic effect of TE on NAFLD. Our findings not only supply systematic insight into the mechanisms of NAFLD but also provide a theoretical basis for the prevention or treatment of NAFLD. |
format | Online Article Text |
id | pubmed-4904104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49041042016-06-30 Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease Wang, Ya Niu, Ming Jia, Ge-liu-chang Li, Rui-sheng Zhang, Ya-ming Zhang, Cong-en Meng, Ya-kun Cui, He-rong Ma, Zhi-jie Li, Dong-hui Wang, Jia-bo Xiao, Xiao-he Evid Based Complement Alternat Med Research Article Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. Currently, there are no recognized medical therapies effective for NAFLD. Previous studies have demonstrated the effects of total turmeric extract on rats with NAFLD induced by high-fat diet. In this study, serum metabolomics was employed using UHPLC-Q-TOF-MS to elucidate the underlying mechanisms of HFD-induced NAFLD and the therapeutic effects of TE. Supervised orthogonal partial least-squares-discriminant analysis was used to discover differentiating metabolites, and pathway enrichment analysis suggested that TE had powerful combined effects of regulating lipid metabolism by affecting glycerophospholipid metabolism, glycerolipid metabolism, and steroid hormone biosynthesis signaling pathways. In addition, the significant changes in glycerophospholipid metabolism proteins also indicated that glycerophospholipid metabolism might be involved in the therapeutic effect of TE on NAFLD. Our findings not only supply systematic insight into the mechanisms of NAFLD but also provide a theoretical basis for the prevention or treatment of NAFLD. Hindawi Publishing Corporation 2016 2016-05-30 /pmc/articles/PMC4904104/ /pubmed/27366193 http://dx.doi.org/10.1155/2016/8495953 Text en Copyright © 2016 Ya Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Ya Niu, Ming Jia, Ge-liu-chang Li, Rui-sheng Zhang, Ya-ming Zhang, Cong-en Meng, Ya-kun Cui, He-rong Ma, Zhi-jie Li, Dong-hui Wang, Jia-bo Xiao, Xiao-he Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease |
title | Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease |
title_full | Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease |
title_fullStr | Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease |
title_full_unstemmed | Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease |
title_short | Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease |
title_sort | untargeted metabolomics reveals intervention effects of total turmeric extract in a rat model of nonalcoholic fatty liver disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904104/ https://www.ncbi.nlm.nih.gov/pubmed/27366193 http://dx.doi.org/10.1155/2016/8495953 |
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