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A Genetic Biomarker of Oxidative Stress, the Paraoxonase-1 Q192R Gene Variant, Associates with Cardiomyopathy in CKD: A Longitudinal Study

Background. Oxidative stress is a hallmark of CKD and this alteration is strongly implicated in LV hypertrophy and in LV dysfunction. Methods and Patients. We resorted to the strongest genetic biomarker of paraoxonase-1 (PON1) activity, the Q192R variant in the PON1 gene, to unbiasedly assess (Mende...

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Detalles Bibliográficos
Autores principales:	Dounousi, E., Bouba, I., Spoto, B., Pappas, K., Tripepi, G., Georgiou, I., Tselepis, A., Elisaf, M., Tsakiris, D., Zoccali, C., Siamopoulos, K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904111/ https://www.ncbi.nlm.nih.gov/pubmed/27313824 http://dx.doi.org/10.1155/2016/1507270

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