Inhibition of Extracellular Calcium Influx Results in Enhanced IL-12 Production in LPS-Treated Murine Macrophages by Downregulation of the CaMKKβ-AMPK-SIRT1 Signaling Pathway

Activated macrophages are the primary sources of IL-12, a key cytokine bridging innate and adaptive immunity. However, macrophages produce low amounts of IL-12 upon stimulation and the underlying regulatory mechanism remains unclear. In this study, we found a new calcium-dependent mechanism that con...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xin, Wang, Ning, Zhu, Yuanfeng, Yang, Yongjun, Chen, Xiaoli, Fan, Shijun, Chen, Qian, Zhou, Hong, Zheng, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904125/
https://www.ncbi.nlm.nih.gov/pubmed/27313401
http://dx.doi.org/10.1155/2016/6152713

Ejemplares similares

Ejemplares similares