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Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development
Gene co-option, usually after gene duplication, in the evolution of development is found to contribute to vertebrate morphological innovations, including the endothelium-based vascular system. Recently, a zebrafish kank gene was found expressed in the vascular vessel primordium, suggesting KANK gene...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904190/ https://www.ncbi.nlm.nih.gov/pubmed/27292017 http://dx.doi.org/10.1038/srep27816 |
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author | Hensley, Monica R. Cui, Zhibin Chua, Rhys F. M. Simpson, Stefanie Shammas, Nicole L. Yang, Jer-Yen Leung, Yuk Fai Zhang, GuangJun |
author_facet | Hensley, Monica R. Cui, Zhibin Chua, Rhys F. M. Simpson, Stefanie Shammas, Nicole L. Yang, Jer-Yen Leung, Yuk Fai Zhang, GuangJun |
author_sort | Hensley, Monica R. |
collection | PubMed |
description | Gene co-option, usually after gene duplication, in the evolution of development is found to contribute to vertebrate morphological innovations, including the endothelium-based vascular system. Recently, a zebrafish kank gene was found expressed in the vascular vessel primordium, suggesting KANK genes are a component of the developmental tool kit for the vertebrate vascular system. However, how the KANK gene family is involved in vascular vessel development during evolution remains largely unknown. First, we analyzed the molecular evolution of the KANK genes in metazoan, and found that KANK1, KANK2, KANK3 and KANK4 emerged in the lineage of vertebrate, consistent with the two rounds of vertebrate whole-genome duplications (WGD). Moreover, KANK genes were further duplicated in teleosts through the bony-fish specific WGD, while only kank1 and kank4 duplicates were retained in some of the examined fish species. We also found all zebrafish kank genes, except kank1b, are primarily expressed during embryonic vascular development. Compared to invertebrate KANK gene expression in the central nervous system, the vascular expression of zebrafish kank genes suggested KANK genes were co-opted for vertebrate vascular development. Given the cellular roles of KANK genes, our results suggest that this co-option may facilitate the evolutionary origin of vertebrate vascular vessels. |
format | Online Article Text |
id | pubmed-4904190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49041902016-06-14 Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development Hensley, Monica R. Cui, Zhibin Chua, Rhys F. M. Simpson, Stefanie Shammas, Nicole L. Yang, Jer-Yen Leung, Yuk Fai Zhang, GuangJun Sci Rep Article Gene co-option, usually after gene duplication, in the evolution of development is found to contribute to vertebrate morphological innovations, including the endothelium-based vascular system. Recently, a zebrafish kank gene was found expressed in the vascular vessel primordium, suggesting KANK genes are a component of the developmental tool kit for the vertebrate vascular system. However, how the KANK gene family is involved in vascular vessel development during evolution remains largely unknown. First, we analyzed the molecular evolution of the KANK genes in metazoan, and found that KANK1, KANK2, KANK3 and KANK4 emerged in the lineage of vertebrate, consistent with the two rounds of vertebrate whole-genome duplications (WGD). Moreover, KANK genes were further duplicated in teleosts through the bony-fish specific WGD, while only kank1 and kank4 duplicates were retained in some of the examined fish species. We also found all zebrafish kank genes, except kank1b, are primarily expressed during embryonic vascular development. Compared to invertebrate KANK gene expression in the central nervous system, the vascular expression of zebrafish kank genes suggested KANK genes were co-opted for vertebrate vascular development. Given the cellular roles of KANK genes, our results suggest that this co-option may facilitate the evolutionary origin of vertebrate vascular vessels. Nature Publishing Group 2016-06-13 /pmc/articles/PMC4904190/ /pubmed/27292017 http://dx.doi.org/10.1038/srep27816 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Hensley, Monica R. Cui, Zhibin Chua, Rhys F. M. Simpson, Stefanie Shammas, Nicole L. Yang, Jer-Yen Leung, Yuk Fai Zhang, GuangJun Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development |
title | Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development |
title_full | Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development |
title_fullStr | Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development |
title_full_unstemmed | Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development |
title_short | Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development |
title_sort | evolutionary and developmental analysis reveals kank genes were co-opted for vertebrate vascular development |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904190/ https://www.ncbi.nlm.nih.gov/pubmed/27292017 http://dx.doi.org/10.1038/srep27816 |
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