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Taurine protects against As(2)O(3)-induced autophagy in livers of rat offsprings through PPARγ pathway
Chronic exposures to arsenic had been associated with metabolism diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) was found in the liver, regulated metabolism. Here, we found that the expression of PPARγ was decreased, the generation of reactive oxygen species (ROS) and autophagy w...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904213/ https://www.ncbi.nlm.nih.gov/pubmed/27291853 http://dx.doi.org/10.1038/srep27733 |
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author | Bai, Jie Yao, Xiaofeng Jiang, Liping Zhang, Qiaoting Guan, Huai Liu, Shuang Wu, Wei Qiu, Tianming Gao, Ni Yang, Lei Yang, Guang Sun, Xiance |
author_facet | Bai, Jie Yao, Xiaofeng Jiang, Liping Zhang, Qiaoting Guan, Huai Liu, Shuang Wu, Wei Qiu, Tianming Gao, Ni Yang, Lei Yang, Guang Sun, Xiance |
author_sort | Bai, Jie |
collection | PubMed |
description | Chronic exposures to arsenic had been associated with metabolism diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) was found in the liver, regulated metabolism. Here, we found that the expression of PPARγ was decreased, the generation of reactive oxygen species (ROS) and autophagy were increased after treatment with As(2)O(3) in offsprings’ livers. Taurine (Tau), a sulfur-containing β–amino acid could reverse As(2)O(3)-inhibited PPARγ. Tau also inhibit the generation of ROS and autophagy. We also found that As(2)O(3) caused autophagic cell death and ROS accelerated in HepG2 cells. Before incubation with As(2)O(3), the cells were pretreated with PPARγ activator Rosiglitazone (RGS), we found that autophagy and ROS was inhibited in HepG2 cells, suggesting that inhibition of PPARγ contributed to As(2)O(3)-induced autophagy and the generation of ROS. After pretreatment with Tau, the level of PPARγ was improved and the autophagy and ROS was inhibited in As(2)O(3)-treated cells, suggesting that Tau could protect hepatocytes against As(2)O(3) through modulating PPARγ pathway. |
format | Online Article Text |
id | pubmed-4904213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49042132016-06-14 Taurine protects against As(2)O(3)-induced autophagy in livers of rat offsprings through PPARγ pathway Bai, Jie Yao, Xiaofeng Jiang, Liping Zhang, Qiaoting Guan, Huai Liu, Shuang Wu, Wei Qiu, Tianming Gao, Ni Yang, Lei Yang, Guang Sun, Xiance Sci Rep Article Chronic exposures to arsenic had been associated with metabolism diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) was found in the liver, regulated metabolism. Here, we found that the expression of PPARγ was decreased, the generation of reactive oxygen species (ROS) and autophagy were increased after treatment with As(2)O(3) in offsprings’ livers. Taurine (Tau), a sulfur-containing β–amino acid could reverse As(2)O(3)-inhibited PPARγ. Tau also inhibit the generation of ROS and autophagy. We also found that As(2)O(3) caused autophagic cell death and ROS accelerated in HepG2 cells. Before incubation with As(2)O(3), the cells were pretreated with PPARγ activator Rosiglitazone (RGS), we found that autophagy and ROS was inhibited in HepG2 cells, suggesting that inhibition of PPARγ contributed to As(2)O(3)-induced autophagy and the generation of ROS. After pretreatment with Tau, the level of PPARγ was improved and the autophagy and ROS was inhibited in As(2)O(3)-treated cells, suggesting that Tau could protect hepatocytes against As(2)O(3) through modulating PPARγ pathway. Nature Publishing Group 2016-06-13 /pmc/articles/PMC4904213/ /pubmed/27291853 http://dx.doi.org/10.1038/srep27733 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Bai, Jie Yao, Xiaofeng Jiang, Liping Zhang, Qiaoting Guan, Huai Liu, Shuang Wu, Wei Qiu, Tianming Gao, Ni Yang, Lei Yang, Guang Sun, Xiance Taurine protects against As(2)O(3)-induced autophagy in livers of rat offsprings through PPARγ pathway |
title | Taurine protects against As(2)O(3)-induced autophagy in livers of rat offsprings through PPARγ pathway |
title_full | Taurine protects against As(2)O(3)-induced autophagy in livers of rat offsprings through PPARγ pathway |
title_fullStr | Taurine protects against As(2)O(3)-induced autophagy in livers of rat offsprings through PPARγ pathway |
title_full_unstemmed | Taurine protects against As(2)O(3)-induced autophagy in livers of rat offsprings through PPARγ pathway |
title_short | Taurine protects against As(2)O(3)-induced autophagy in livers of rat offsprings through PPARγ pathway |
title_sort | taurine protects against as(2)o(3)-induced autophagy in livers of rat offsprings through pparγ pathway |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904213/ https://www.ncbi.nlm.nih.gov/pubmed/27291853 http://dx.doi.org/10.1038/srep27733 |
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