Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing

When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren's syndrome and rheumatoid arthriti...

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Detalles Bibliográficos
Autores principales: Li, Pen, Cheung, Lawrence, Chiu, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Clinico-Pathologic Conferences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904558/
https://www.ncbi.nlm.nih.gov/pubmed/27445561
http://dx.doi.org/10.1155/2016/7056035
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author Li, Pen
Cheung, Lawrence
Chiu, Brian
author_facet Li, Pen
Cheung, Lawrence
Chiu, Brian
author_sort Li, Pen
collection PubMed
description When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren's syndrome and rheumatoid arthritis with dyspnea and imaging consistent with lymphoid interstitial pneumonia (LIP). However, while histology and immunohistochemistry lacked definitive features of a lymphoma, immunoglobulin heavy chain (IgH) polymerase chain reaction testing demonstrated B-cell monoclonality, consistent with an early BALT lymphoma.
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spelling pubmed-49045582016-06-30 Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing Li, Pen Cheung, Lawrence Chiu, Brian Can Respir J Clinico-Pathologic Conferences When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren's syndrome and rheumatoid arthritis with dyspnea and imaging consistent with lymphoid interstitial pneumonia (LIP). However, while histology and immunohistochemistry lacked definitive features of a lymphoma, immunoglobulin heavy chain (IgH) polymerase chain reaction testing demonstrated B-cell monoclonality, consistent with an early BALT lymphoma. Hindawi Publishing Corporation 2016 2016-03-31 /pmc/articles/PMC4904558/ /pubmed/27445561 http://dx.doi.org/10.1155/2016/7056035 Text en Copyright © 2016 Pen Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinico-Pathologic Conferences
Li, Pen
Cheung, Lawrence
Chiu, Brian
Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_full Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_fullStr Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_full_unstemmed Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_short Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing
title_sort early bronchus-associated lymphoid tissue lymphoma diagnosed with immunoglobulin heavy chain molecular testing
topic Clinico-Pathologic Conferences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904558/
https://www.ncbi.nlm.nih.gov/pubmed/27445561
http://dx.doi.org/10.1155/2016/7056035
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AT chiubrian earlybronchusassociatedlymphoidtissuelymphomadiagnosedwithimmunoglobulinheavychainmoleculartesting

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