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Death of a 29-Year-Old Male from Undifferentiated Sepsis

Tumour necrosis factor alpha inhibitors, such as infliximab, and other biologic agents are associated with increased risk of opportunistic infection, including tuberculosis. Tuberculosis infections associated with infliximab tend to present atypically and can be difficult to diagnose, as they are mo...

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Autores principales: Trebuss, Kathryn A., Buttemer, Samantha, Wilkinson, Jeffrey S., Xu, Josie, Rossiter, John P., Moore, Kieran M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904581/
https://www.ncbi.nlm.nih.gov/pubmed/27366159
http://dx.doi.org/10.1155/2016/2478924
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author Trebuss, Kathryn A.
Buttemer, Samantha
Wilkinson, Jeffrey S.
Xu, Josie
Rossiter, John P.
Moore, Kieran M.
author_facet Trebuss, Kathryn A.
Buttemer, Samantha
Wilkinson, Jeffrey S.
Xu, Josie
Rossiter, John P.
Moore, Kieran M.
author_sort Trebuss, Kathryn A.
collection PubMed
description Tumour necrosis factor alpha inhibitors, such as infliximab, and other biologic agents are associated with increased risk of opportunistic infection, including tuberculosis. Tuberculosis infections associated with infliximab tend to present atypically and can be difficult to diagnose, as they are more likely to manifest as extrapulmonary or disseminated disease. The authors report a case involving a 29-year-old male patient who died following 16 days of treatment for undifferentiated sepsis and who was found on autopsy to have widespread disseminated tuberculosis. Prior to the onset of illness, the patient had received infliximab for the treatment of Crohn's disease. Following discussion of the case, the authors review the definition of adverse events, provide a root cause analysis of the cognitive errors and breakdowns in the health care system that contributed to the reported outcome, and identify opportunities to address these breakdowns and improve patient safety measures for future cases.
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spelling pubmed-49045812016-06-30 Death of a 29-Year-Old Male from Undifferentiated Sepsis Trebuss, Kathryn A. Buttemer, Samantha Wilkinson, Jeffrey S. Xu, Josie Rossiter, John P. Moore, Kieran M. Can J Infect Dis Med Microbiol Case Report Tumour necrosis factor alpha inhibitors, such as infliximab, and other biologic agents are associated with increased risk of opportunistic infection, including tuberculosis. Tuberculosis infections associated with infliximab tend to present atypically and can be difficult to diagnose, as they are more likely to manifest as extrapulmonary or disseminated disease. The authors report a case involving a 29-year-old male patient who died following 16 days of treatment for undifferentiated sepsis and who was found on autopsy to have widespread disseminated tuberculosis. Prior to the onset of illness, the patient had received infliximab for the treatment of Crohn's disease. Following discussion of the case, the authors review the definition of adverse events, provide a root cause analysis of the cognitive errors and breakdowns in the health care system that contributed to the reported outcome, and identify opportunities to address these breakdowns and improve patient safety measures for future cases. Hindawi Publishing Corporation 2016 2016-03-30 /pmc/articles/PMC4904581/ /pubmed/27366159 http://dx.doi.org/10.1155/2016/2478924 Text en Copyright © 2016 Kathryn A. Trebuss et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Trebuss, Kathryn A.
Buttemer, Samantha
Wilkinson, Jeffrey S.
Xu, Josie
Rossiter, John P.
Moore, Kieran M.
Death of a 29-Year-Old Male from Undifferentiated Sepsis
title Death of a 29-Year-Old Male from Undifferentiated Sepsis
title_full Death of a 29-Year-Old Male from Undifferentiated Sepsis
title_fullStr Death of a 29-Year-Old Male from Undifferentiated Sepsis
title_full_unstemmed Death of a 29-Year-Old Male from Undifferentiated Sepsis
title_short Death of a 29-Year-Old Male from Undifferentiated Sepsis
title_sort death of a 29-year-old male from undifferentiated sepsis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904581/
https://www.ncbi.nlm.nih.gov/pubmed/27366159
http://dx.doi.org/10.1155/2016/2478924
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