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Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients

Background. Features of nonalcoholic fatty liver disease (NAFLD) have yet to be described in the Canadian First Nations (FN) population. The aim of this study was to compare the prevalence, severity, and outcome of NAFLD in FN versus non-FN patients at an urban, tertiary care centre. Methods. Adults...

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Autores principales: Uhanova, Julia, Minuk, Gerald, Lopez Ficher, Federico, Chandok, Natasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904639/
https://www.ncbi.nlm.nih.gov/pubmed/27446857
http://dx.doi.org/10.1155/2016/6420408
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author Uhanova, Julia
Minuk, Gerald
Lopez Ficher, Federico
Chandok, Natasha
author_facet Uhanova, Julia
Minuk, Gerald
Lopez Ficher, Federico
Chandok, Natasha
author_sort Uhanova, Julia
collection PubMed
description Background. Features of nonalcoholic fatty liver disease (NAFLD) have yet to be described in the Canadian First Nations (FN) population. The aim of this study was to compare the prevalence, severity, and outcome of NAFLD in FN versus non-FN patients at an urban, tertiary care centre. Methods. Adults with NAFLD and no additional liver disease were identified in a prospectively derived database at the University of Manitoba. Demographic, clinical, laboratory, imaging, and histologic data were analyzed. Results. 482 subjects fulfilled diagnostic criteria for NAFLD, including 33 (7%) FN. Aside from rural residence, diabetes and cholestasis being more common in FN patients, the ages, gender distributions, clinical and radiologic features, and liver enzyme/function test results were similar in the two cohorts. Noninvasive tests of fibrosis (APRI and NAFLD fibrosis scores) were also similar in the two cohorts. There were no significant differences in liver enzyme or function tests in either cohort after approximately three years of follow-up. Conclusion. Compared to the prevalence of FN persons in the general population of this study site (10–15%), FN patients were underrepresented in this NAFLD population. The severity and progression of liver disease in FN patients appear to be similar to those in non-FN patients.
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spelling pubmed-49046392016-06-30 Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients Uhanova, Julia Minuk, Gerald Lopez Ficher, Federico Chandok, Natasha Can J Gastroenterol Hepatol Research Article Background. Features of nonalcoholic fatty liver disease (NAFLD) have yet to be described in the Canadian First Nations (FN) population. The aim of this study was to compare the prevalence, severity, and outcome of NAFLD in FN versus non-FN patients at an urban, tertiary care centre. Methods. Adults with NAFLD and no additional liver disease were identified in a prospectively derived database at the University of Manitoba. Demographic, clinical, laboratory, imaging, and histologic data were analyzed. Results. 482 subjects fulfilled diagnostic criteria for NAFLD, including 33 (7%) FN. Aside from rural residence, diabetes and cholestasis being more common in FN patients, the ages, gender distributions, clinical and radiologic features, and liver enzyme/function test results were similar in the two cohorts. Noninvasive tests of fibrosis (APRI and NAFLD fibrosis scores) were also similar in the two cohorts. There were no significant differences in liver enzyme or function tests in either cohort after approximately three years of follow-up. Conclusion. Compared to the prevalence of FN persons in the general population of this study site (10–15%), FN patients were underrepresented in this NAFLD population. The severity and progression of liver disease in FN patients appear to be similar to those in non-FN patients. Hindawi Publishing Corporation 2016 2016-04-28 /pmc/articles/PMC4904639/ /pubmed/27446857 http://dx.doi.org/10.1155/2016/6420408 Text en Copyright © 2016 Julia Uhanova et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Uhanova, Julia
Minuk, Gerald
Lopez Ficher, Federico
Chandok, Natasha
Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients
title Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients
title_full Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients
title_fullStr Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients
title_full_unstemmed Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients
title_short Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients
title_sort nonalcoholic fatty liver disease in canadian first nations and non-first nations patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904639/
https://www.ncbi.nlm.nih.gov/pubmed/27446857
http://dx.doi.org/10.1155/2016/6420408
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