Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling

The introduction of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus greatly reduced the rate of allograft rejection, although their chronic use is marred by a range of side effects, among them vascular toxicity. In transplant patients, it is proved that innate immunity promotes vascula...

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Detalles Bibliográficos
Autores principales: Rodrigues-Diez, Raquel, González-Guerrero, Cristian, Ocaña-Salceda, Carlos, Rodrigues-Diez, Raúl R., Egido, Jesús, Ortiz, Alberto, Ruiz-Ortega, Marta, Ramos, Adrián M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904742/
https://www.ncbi.nlm.nih.gov/pubmed/27295076
http://dx.doi.org/10.1038/srep27915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904742/
https://www.ncbi.nlm.nih.gov/pubmed/27295076
http://dx.doi.org/10.1038/srep27915

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