Cargando…
Selenoprotein M is expressed during bone development
25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational processing of proteins and maintenance of ER func...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Leibniz Research Centre for Working Environment and Human Factors
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904744/ https://www.ncbi.nlm.nih.gov/pubmed/27298612 |
_version_ | 1782437194176135168 |
---|---|
author | Grosch, Melanie Fuchs, Jennifer Bösl, Michael Winterpacht, Andreas Tagariello, Andreas |
author_facet | Grosch, Melanie Fuchs, Jennifer Bösl, Michael Winterpacht, Andreas Tagariello, Andreas |
author_sort | Grosch, Melanie |
collection | PubMed |
description | 25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational processing of proteins and maintenance of ER function. Since SELM was overrepresented in a cartilage- and bone-specific expressed sequence tag (EST) library, we further investigated the expression pattern of Selm and its possible biological function in the skeleton. RNA in situ hybridization of Selm in chicken and mice of different developmental stages revealed prominent expression in bones, specifically in osteoblast, and in tendons. This result suggests that SELM functions during bone development, where it is possibly involved in the processing of secreted proteins. |
format | Online Article Text |
id | pubmed-4904744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Leibniz Research Centre for Working Environment and Human Factors |
record_format | MEDLINE/PubMed |
spelling | pubmed-49047442016-06-13 Selenoprotein M is expressed during bone development Grosch, Melanie Fuchs, Jennifer Bösl, Michael Winterpacht, Andreas Tagariello, Andreas EXCLI J Original Article 25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational processing of proteins and maintenance of ER function. Since SELM was overrepresented in a cartilage- and bone-specific expressed sequence tag (EST) library, we further investigated the expression pattern of Selm and its possible biological function in the skeleton. RNA in situ hybridization of Selm in chicken and mice of different developmental stages revealed prominent expression in bones, specifically in osteoblast, and in tendons. This result suggests that SELM functions during bone development, where it is possibly involved in the processing of secreted proteins. Leibniz Research Centre for Working Environment and Human Factors 2013-11-20 /pmc/articles/PMC4904744/ /pubmed/27298612 Text en Copyright © 2013 Grosch et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Original Article Grosch, Melanie Fuchs, Jennifer Bösl, Michael Winterpacht, Andreas Tagariello, Andreas Selenoprotein M is expressed during bone development |
title | Selenoprotein M is expressed during bone development |
title_full | Selenoprotein M is expressed during bone development |
title_fullStr | Selenoprotein M is expressed during bone development |
title_full_unstemmed | Selenoprotein M is expressed during bone development |
title_short | Selenoprotein M is expressed during bone development |
title_sort | selenoprotein m is expressed during bone development |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904744/ https://www.ncbi.nlm.nih.gov/pubmed/27298612 |
work_keys_str_mv | AT groschmelanie selenoproteinmisexpressedduringbonedevelopment AT fuchsjennifer selenoproteinmisexpressedduringbonedevelopment AT boslmichael selenoproteinmisexpressedduringbonedevelopment AT winterpachtandreas selenoproteinmisexpressedduringbonedevelopment AT tagarielloandreas selenoproteinmisexpressedduringbonedevelopment |