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Selenoprotein M is expressed during bone development

25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational processing of proteins and maintenance of ER func...

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Autores principales: Grosch, Melanie, Fuchs, Jennifer, Bösl, Michael, Winterpacht, Andreas, Tagariello, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904744/
https://www.ncbi.nlm.nih.gov/pubmed/27298612
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author Grosch, Melanie
Fuchs, Jennifer
Bösl, Michael
Winterpacht, Andreas
Tagariello, Andreas
author_facet Grosch, Melanie
Fuchs, Jennifer
Bösl, Michael
Winterpacht, Andreas
Tagariello, Andreas
author_sort Grosch, Melanie
collection PubMed
description 25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational processing of proteins and maintenance of ER function. Since SELM was overrepresented in a cartilage- and bone-specific expressed sequence tag (EST) library, we further investigated the expression pattern of Selm and its possible biological function in the skeleton. RNA in situ hybridization of Selm in chicken and mice of different developmental stages revealed prominent expression in bones, specifically in osteoblast, and in tendons. This result suggests that SELM functions during bone development, where it is possibly involved in the processing of secreted proteins.
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spelling pubmed-49047442016-06-13 Selenoprotein M is expressed during bone development Grosch, Melanie Fuchs, Jennifer Bösl, Michael Winterpacht, Andreas Tagariello, Andreas EXCLI J Original Article 25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational processing of proteins and maintenance of ER function. Since SELM was overrepresented in a cartilage- and bone-specific expressed sequence tag (EST) library, we further investigated the expression pattern of Selm and its possible biological function in the skeleton. RNA in situ hybridization of Selm in chicken and mice of different developmental stages revealed prominent expression in bones, specifically in osteoblast, and in tendons. This result suggests that SELM functions during bone development, where it is possibly involved in the processing of secreted proteins. Leibniz Research Centre for Working Environment and Human Factors 2013-11-20 /pmc/articles/PMC4904744/ /pubmed/27298612 Text en Copyright © 2013 Grosch et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Grosch, Melanie
Fuchs, Jennifer
Bösl, Michael
Winterpacht, Andreas
Tagariello, Andreas
Selenoprotein M is expressed during bone development
title Selenoprotein M is expressed during bone development
title_full Selenoprotein M is expressed during bone development
title_fullStr Selenoprotein M is expressed during bone development
title_full_unstemmed Selenoprotein M is expressed during bone development
title_short Selenoprotein M is expressed during bone development
title_sort selenoprotein m is expressed during bone development
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904744/
https://www.ncbi.nlm.nih.gov/pubmed/27298612
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