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Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder
Hyperprolactinemia is a common adverse effect of antipsychotic medication. Switching over to aripiprazole or adjunctive aripiprazole has been advocated for optimal management of antipsychotic-induced hyperprolactinemia. Adjunctive treatment with aripiprazole has been shown to normalize prolactin lev...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904767/ https://www.ncbi.nlm.nih.gov/pubmed/27335526 http://dx.doi.org/10.4103/0253-7176.183082 |
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author | Joseph, Sam Padamadan |
author_facet | Joseph, Sam Padamadan |
author_sort | Joseph, Sam Padamadan |
collection | PubMed |
description | Hyperprolactinemia is a common adverse effect of antipsychotic medication. Switching over to aripiprazole or adjunctive aripiprazole has been advocated for optimal management of antipsychotic-induced hyperprolactinemia. Adjunctive treatment with aripiprazole has been shown to normalize prolactin levels without affecting already achieved improvements in psychotic symptoms. However, here, we present the case of a 36 year old female with delusional disorder who developed symptomatic hyperprolactinemia while on aripiprazole treatment. Dopamine acts as a tonic inhibitor of prolactin secretion through the tubero-infundibular dopaminergic system. Aripiprazole being a partial agonist has a lower intrinsic activity at the D2 receptor than dopamine, allowing it to act as both, a functional agonist and antagonist, depending on the surrounding levels of dopamine. Hence, in the absence of a competing D2 antagonist and the presence of dopamine (the natural agonist), aripiprazole could act as a functional antagonist and thus elevate prolactin levels. |
format | Online Article Text |
id | pubmed-4904767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49047672016-06-22 Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder Joseph, Sam Padamadan Indian J Psychol Med Case Report Hyperprolactinemia is a common adverse effect of antipsychotic medication. Switching over to aripiprazole or adjunctive aripiprazole has been advocated for optimal management of antipsychotic-induced hyperprolactinemia. Adjunctive treatment with aripiprazole has been shown to normalize prolactin levels without affecting already achieved improvements in psychotic symptoms. However, here, we present the case of a 36 year old female with delusional disorder who developed symptomatic hyperprolactinemia while on aripiprazole treatment. Dopamine acts as a tonic inhibitor of prolactin secretion through the tubero-infundibular dopaminergic system. Aripiprazole being a partial agonist has a lower intrinsic activity at the D2 receptor than dopamine, allowing it to act as both, a functional agonist and antagonist, depending on the surrounding levels of dopamine. Hence, in the absence of a competing D2 antagonist and the presence of dopamine (the natural agonist), aripiprazole could act as a functional antagonist and thus elevate prolactin levels. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4904767/ /pubmed/27335526 http://dx.doi.org/10.4103/0253-7176.183082 Text en Copyright: © Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Joseph, Sam Padamadan Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder |
title | Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder |
title_full | Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder |
title_fullStr | Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder |
title_full_unstemmed | Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder |
title_short | Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder |
title_sort | aripiprazole-induced hyperprolactinemia in a young female with delusional disorder |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904767/ https://www.ncbi.nlm.nih.gov/pubmed/27335526 http://dx.doi.org/10.4103/0253-7176.183082 |
work_keys_str_mv | AT josephsampadamadan aripiprazoleinducedhyperprolactinemiainayoungfemalewithdelusionaldisorder |