NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR

NIPBL, a cohesin loader, has been implicated in transcriptional control and genome organization. Mutations in NIPBL, cohesin, and its deacetylase HDAC8 result in Cornelia de Lange syndrome. We report activation of the RNA-sensing kinase PKR in human lymphoblastoid cell lines carrying NIPBL or HDAC8...

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Detalles Bibliográficos
Autores principales: Yuen, Kobe C., Xu, Baoshan, Krantz, Ian D., Gerton, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904785/
https://www.ncbi.nlm.nih.gov/pubmed/26725122
http://dx.doi.org/10.1016/j.celrep.2015.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904785/
https://www.ncbi.nlm.nih.gov/pubmed/26725122
http://dx.doi.org/10.1016/j.celrep.2015.12.012

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