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NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR
NIPBL, a cohesin loader, has been implicated in transcriptional control and genome organization. Mutations in NIPBL, cohesin, and its deacetylase HDAC8 result in Cornelia de Lange syndrome. We report activation of the RNA-sensing kinase PKR in human lymphoblastoid cell lines carrying NIPBL or HDAC8...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904785/ https://www.ncbi.nlm.nih.gov/pubmed/26725122 http://dx.doi.org/10.1016/j.celrep.2015.12.012 |