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A new “angle” on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition
The MYCN oncoprotein has remained an elusive target for decades. We recently reported a new class of kinase inhibitors designed to disrupt the conformation of Aurora kinase A enough to block its kinase-independent interaction with MYCN, resulting in potent degradation of MYCN. These studies provide...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904880/ https://www.ncbi.nlm.nih.gov/pubmed/27308435 http://dx.doi.org/10.4161/23723556.2014.975641 |