TRIM32 is a novel negative regulator of p53

To ensure proper function, the tumor suppressor p53 is tightly regulated through different post-translational modifications, particularly ubiquitination. Recently, TRIM32 was identified as a p53-regulated gene and an E3 ubiquitin ligase of p53. Thus, TRIM32 and p53 form a novel auto-regulatory negat...

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Detalles Bibliográficos
Autores principales: Liu, Juan, Zhu, Yu, Hu, Wenwei, Feng, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904883/
https://www.ncbi.nlm.nih.gov/pubmed/27308422
http://dx.doi.org/10.4161/23723548.2014.970951
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author Liu, Juan
Zhu, Yu
Hu, Wenwei
Feng, Zhaohui
author_facet Liu, Juan
Zhu, Yu
Hu, Wenwei
Feng, Zhaohui
author_sort Liu, Juan
collection PubMed
description To ensure proper function, the tumor suppressor p53 is tightly regulated through different post-translational modifications, particularly ubiquitination. Recently, TRIM32 was identified as a p53-regulated gene and an E3 ubiquitin ligase of p53. Thus, TRIM32 and p53 form a novel auto-regulatory negative feedback loop for p53 regulation in cells.
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spelling pubmed-49048832016-06-15 TRIM32 is a novel negative regulator of p53 Liu, Juan Zhu, Yu Hu, Wenwei Feng, Zhaohui Mol Cell Oncol Author'S View To ensure proper function, the tumor suppressor p53 is tightly regulated through different post-translational modifications, particularly ubiquitination. Recently, TRIM32 was identified as a p53-regulated gene and an E3 ubiquitin ligase of p53. Thus, TRIM32 and p53 form a novel auto-regulatory negative feedback loop for p53 regulation in cells. Taylor & Francis 2014-12-01 /pmc/articles/PMC4904883/ /pubmed/27308422 http://dx.doi.org/10.4161/23723548.2014.970951 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Liu, Juan
Zhu, Yu
Hu, Wenwei
Feng, Zhaohui
TRIM32 is a novel negative regulator of p53
title TRIM32 is a novel negative regulator of p53
title_full TRIM32 is a novel negative regulator of p53
title_fullStr TRIM32 is a novel negative regulator of p53
title_full_unstemmed TRIM32 is a novel negative regulator of p53
title_short TRIM32 is a novel negative regulator of p53
title_sort trim32 is a novel negative regulator of p53
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904883/
https://www.ncbi.nlm.nih.gov/pubmed/27308422
http://dx.doi.org/10.4161/23723548.2014.970951
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