How do telomeres and NHEJ coexist?

The telomeres of eukaryotes are stable open double-strand ends that coexist with nonhomologous end joining (NHEJ), the repair pathway that directly ligates DNA ends generated by double-strand breaks. Since a single end-joining event between 2 telomeres generates a circular chromosome or an unstable...

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Detalles Bibliográficos
Autor principal: Marcand, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904885/
https://www.ncbi.nlm.nih.gov/pubmed/27308342
http://dx.doi.org/10.4161/23723548.2014.963438
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author Marcand, Stéphane
author_facet Marcand, Stéphane
author_sort Marcand, Stéphane
collection PubMed
description The telomeres of eukaryotes are stable open double-strand ends that coexist with nonhomologous end joining (NHEJ), the repair pathway that directly ligates DNA ends generated by double-strand breaks. Since a single end-joining event between 2 telomeres generates a circular chromosome or an unstable dicentric chromosome, NHEJ must be prevented from acting on telomeres. Multiple mechanisms mediated by telomere factors act in synergy to achieve this inhibition.
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spelling pubmed-49048852016-06-15 How do telomeres and NHEJ coexist? Marcand, Stéphane Mol Cell Oncol Review The telomeres of eukaryotes are stable open double-strand ends that coexist with nonhomologous end joining (NHEJ), the repair pathway that directly ligates DNA ends generated by double-strand breaks. Since a single end-joining event between 2 telomeres generates a circular chromosome or an unstable dicentric chromosome, NHEJ must be prevented from acting on telomeres. Multiple mechanisms mediated by telomere factors act in synergy to achieve this inhibition. Taylor & Francis 2014-10-29 /pmc/articles/PMC4904885/ /pubmed/27308342 http://dx.doi.org/10.4161/23723548.2014.963438 Text en © 2014 The Author(s). 2014 Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Marcand, Stéphane
How do telomeres and NHEJ coexist?
title How do telomeres and NHEJ coexist?
title_full How do telomeres and NHEJ coexist?
title_fullStr How do telomeres and NHEJ coexist?
title_full_unstemmed How do telomeres and NHEJ coexist?
title_short How do telomeres and NHEJ coexist?
title_sort how do telomeres and nhej coexist?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904885/
https://www.ncbi.nlm.nih.gov/pubmed/27308342
http://dx.doi.org/10.4161/23723548.2014.963438
work_keys_str_mv AT marcandstephane howdotelomeresandnhejcoexist

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