VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis

Vascular endothelial growth factor (VEGF) activates unfolded protein response sensors in the endoplasmic reticulum through phospholipase C gamma (PLCγ)-mediated crosstalk with mammalian target of rapamycin complex 1 (mTORC1). Activation of transcription factor 6 (ATF6) and protein kinase RNA-like en...

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Autores principales: Karali, Evdoxia, Bellou, Sofia, Stellas, Dimitris, Klinakis, Apostolos, Murphy, Carol, Fotsis, Theodore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904886/
https://www.ncbi.nlm.nih.gov/pubmed/27308350
http://dx.doi.org/10.4161/23723548.2014.964024
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author Karali, Evdoxia
Bellou, Sofia
Stellas, Dimitris
Klinakis, Apostolos
Murphy, Carol
Fotsis, Theodore
author_facet Karali, Evdoxia
Bellou, Sofia
Stellas, Dimitris
Klinakis, Apostolos
Murphy, Carol
Fotsis, Theodore
author_sort Karali, Evdoxia
collection PubMed
description Vascular endothelial growth factor (VEGF) activates unfolded protein response sensors in the endoplasmic reticulum through phospholipase C gamma (PLCγ)-mediated crosstalk with mammalian target of rapamycin complex 1 (mTORC1). Activation of transcription factor 6 (ATF6) and protein kinase RNA-like endoplasmic reticulum kinase (PERK) activate mTORC2, ensuring maximal endothelial cell survival and angiogenic activity through phosphorylation of AKT on Ser473. As mTORC1 is a metabolic sensor, metabolic signals may be integrated with signals from VEGF in the regulation of angiogenesis.
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spelling pubmed-49048862016-06-15 VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis Karali, Evdoxia Bellou, Sofia Stellas, Dimitris Klinakis, Apostolos Murphy, Carol Fotsis, Theodore Mol Cell Oncol Author's View Vascular endothelial growth factor (VEGF) activates unfolded protein response sensors in the endoplasmic reticulum through phospholipase C gamma (PLCγ)-mediated crosstalk with mammalian target of rapamycin complex 1 (mTORC1). Activation of transcription factor 6 (ATF6) and protein kinase RNA-like endoplasmic reticulum kinase (PERK) activate mTORC2, ensuring maximal endothelial cell survival and angiogenic activity through phosphorylation of AKT on Ser473. As mTORC1 is a metabolic sensor, metabolic signals may be integrated with signals from VEGF in the regulation of angiogenesis. Taylor & Francis 2014-12-23 /pmc/articles/PMC4904886/ /pubmed/27308350 http://dx.doi.org/10.4161/23723548.2014.964024 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Karali, Evdoxia
Bellou, Sofia
Stellas, Dimitris
Klinakis, Apostolos
Murphy, Carol
Fotsis, Theodore
VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
title VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
title_full VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
title_fullStr VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
title_full_unstemmed VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
title_short VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
title_sort vegf signaling, mtor complexes, and the endoplasmic reticulum: towards a role of metabolic sensing in the regulation of angiogenesis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904886/
https://www.ncbi.nlm.nih.gov/pubmed/27308350
http://dx.doi.org/10.4161/23723548.2014.964024
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