Moving ahead on harnessing synthetic lethality to fight cancer

We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, dru...

Descripción completa

Detalles Bibliográficos
Autores principales: Jerby-Arnon, Livnat, Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904895/
https://www.ncbi.nlm.nih.gov/pubmed/27308440
http://dx.doi.org/10.4161/23723556.2014.977150
_version_ 1782437207307452416
author Jerby-Arnon, Livnat
Ruppin, Eytan
author_facet Jerby-Arnon, Livnat
Ruppin, Eytan
author_sort Jerby-Arnon, Livnat
collection PubMed
description We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer.
format Online
Article
Text
id pubmed-4904895
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49048952016-06-15 Moving ahead on harnessing synthetic lethality to fight cancer Jerby-Arnon, Livnat Ruppin, Eytan Mol Cell Oncol Author'S View We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer. Taylor & Francis 2015-02-25 /pmc/articles/PMC4904895/ /pubmed/27308440 http://dx.doi.org/10.4161/23723556.2014.977150 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Jerby-Arnon, Livnat
Ruppin, Eytan
Moving ahead on harnessing synthetic lethality to fight cancer
title Moving ahead on harnessing synthetic lethality to fight cancer
title_full Moving ahead on harnessing synthetic lethality to fight cancer
title_fullStr Moving ahead on harnessing synthetic lethality to fight cancer
title_full_unstemmed Moving ahead on harnessing synthetic lethality to fight cancer
title_short Moving ahead on harnessing synthetic lethality to fight cancer
title_sort moving ahead on harnessing synthetic lethality to fight cancer
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904895/
https://www.ncbi.nlm.nih.gov/pubmed/27308440
http://dx.doi.org/10.4161/23723556.2014.977150
work_keys_str_mv AT jerbyarnonlivnat movingaheadonharnessingsyntheticlethalitytofightcancer
AT ruppineytan movingaheadonharnessingsyntheticlethalitytofightcancer

Ejemplares similares