The PVT1-MYC duet in cancer

Gain of 8q24, harboring the avian myelocytomatosis viral oncogene homolog (MYC), is a frequent mutation in cancers. Although MYC is the usual suspect in these cancers, the role of other co-gained loci remains mostly unknown. We have recently found that MYC partners with the adjacent long non-coding...

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Autores principales: Tseng, Yuen-Yi, Bagchi, Anindya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904896/
https://www.ncbi.nlm.nih.gov/pubmed/27308428
http://dx.doi.org/10.4161/23723556.2014.974467
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author Tseng, Yuen-Yi
Bagchi, Anindya
author_facet Tseng, Yuen-Yi
Bagchi, Anindya
author_sort Tseng, Yuen-Yi
collection PubMed
description Gain of 8q24, harboring the avian myelocytomatosis viral oncogene homolog (MYC), is a frequent mutation in cancers. Although MYC is the usual suspect in these cancers, the role of other co-gained loci remains mostly unknown. We have recently found that MYC partners with the adjacent long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1), which stabilizes MYC protein and potentiates its activity.
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spelling pubmed-49048962016-06-15 The PVT1-MYC duet in cancer Tseng, Yuen-Yi Bagchi, Anindya Mol Cell Oncol Author'S View Gain of 8q24, harboring the avian myelocytomatosis viral oncogene homolog (MYC), is a frequent mutation in cancers. Although MYC is the usual suspect in these cancers, the role of other co-gained loci remains mostly unknown. We have recently found that MYC partners with the adjacent long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1), which stabilizes MYC protein and potentiates its activity. Taylor & Francis 2015-02-11 /pmc/articles/PMC4904896/ /pubmed/27308428 http://dx.doi.org/10.4161/23723556.2014.974467 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Tseng, Yuen-Yi
Bagchi, Anindya
The PVT1-MYC duet in cancer
title The PVT1-MYC duet in cancer
title_full The PVT1-MYC duet in cancer
title_fullStr The PVT1-MYC duet in cancer
title_full_unstemmed The PVT1-MYC duet in cancer
title_short The PVT1-MYC duet in cancer
title_sort pvt1-myc duet in cancer
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904896/
https://www.ncbi.nlm.nih.gov/pubmed/27308428
http://dx.doi.org/10.4161/23723556.2014.974467
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