The control of tumor vessels: what you would not expect from a neural adhesion molecule

The neural adhesion molecule L1 is involved in development and plasticity of the nervous system. We recently reported aberrant expression of L1 in the vasculature of various human tumor types. Genetic and functional inactivation of endothelial L1 in a mouse tumor model resulted in decreased tumor an...

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Detalles Bibliográficos
Autores principales: Angiolini, Francesca, Cavallaro, Ugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904897/
https://www.ncbi.nlm.nih.gov/pubmed/27308446
http://dx.doi.org/10.4161/23723556.2014.982045
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author Angiolini, Francesca
Cavallaro, Ugo
author_facet Angiolini, Francesca
Cavallaro, Ugo
author_sort Angiolini, Francesca
collection PubMed
description The neural adhesion molecule L1 is involved in development and plasticity of the nervous system. We recently reported aberrant expression of L1 in the vasculature of various human tumor types. Genetic and functional inactivation of endothelial L1 in a mouse tumor model resulted in decreased tumor angiogenesis and promoted vascular normalization. Thus, endothelial L1 might represent a novel therapeutic target for vessel-targeted treatments of solid tumors.
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spelling pubmed-49048972016-06-15 The control of tumor vessels: what you would not expect from a neural adhesion molecule Angiolini, Francesca Cavallaro, Ugo Mol Cell Oncol Author'S View The neural adhesion molecule L1 is involved in development and plasticity of the nervous system. We recently reported aberrant expression of L1 in the vasculature of various human tumor types. Genetic and functional inactivation of endothelial L1 in a mouse tumor model resulted in decreased tumor angiogenesis and promoted vascular normalization. Thus, endothelial L1 might represent a novel therapeutic target for vessel-targeted treatments of solid tumors. Taylor & Francis 2015-03-18 /pmc/articles/PMC4904897/ /pubmed/27308446 http://dx.doi.org/10.4161/23723556.2014.982045 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Angiolini, Francesca
Cavallaro, Ugo
The control of tumor vessels: what you would not expect from a neural adhesion molecule
title The control of tumor vessels: what you would not expect from a neural adhesion molecule
title_full The control of tumor vessels: what you would not expect from a neural adhesion molecule
title_fullStr The control of tumor vessels: what you would not expect from a neural adhesion molecule
title_full_unstemmed The control of tumor vessels: what you would not expect from a neural adhesion molecule
title_short The control of tumor vessels: what you would not expect from a neural adhesion molecule
title_sort control of tumor vessels: what you would not expect from a neural adhesion molecule
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904897/
https://www.ncbi.nlm.nih.gov/pubmed/27308446
http://dx.doi.org/10.4161/23723556.2014.982045
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