Aneuploidy and proteotoxic stress in cancer

Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuplo...

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Detalles Bibliográficos
Autores principales: Donnelly, Neysan, Storchová, Zuzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904904/
https://www.ncbi.nlm.nih.gov/pubmed/27308438
http://dx.doi.org/10.4161/23723556.2014.976491
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author Donnelly, Neysan
Storchová, Zuzana
author_facet Donnelly, Neysan
Storchová, Zuzana
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description Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuploidy and proteotoxic stress. Further, our findings implicate HSF1 as a key factor in mitigating the effects of aneuploidy.
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spelling pubmed-49049042016-06-15 Aneuploidy and proteotoxic stress in cancer Donnelly, Neysan Storchová, Zuzana Mol Cell Oncol Author'S View Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuploidy and proteotoxic stress. Further, our findings implicate HSF1 as a key factor in mitigating the effects of aneuploidy. Taylor & Francis 2015-02-25 /pmc/articles/PMC4904904/ /pubmed/27308438 http://dx.doi.org/10.4161/23723556.2014.976491 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Donnelly, Neysan
Storchová, Zuzana
Aneuploidy and proteotoxic stress in cancer
title Aneuploidy and proteotoxic stress in cancer
title_full Aneuploidy and proteotoxic stress in cancer
title_fullStr Aneuploidy and proteotoxic stress in cancer
title_full_unstemmed Aneuploidy and proteotoxic stress in cancer
title_short Aneuploidy and proteotoxic stress in cancer
title_sort aneuploidy and proteotoxic stress in cancer
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904904/
https://www.ncbi.nlm.nih.gov/pubmed/27308438
http://dx.doi.org/10.4161/23723556.2014.976491
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