Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer

Squamous lung cancer is a subtype of non-small cell lung cancer with a poor overall prognosis. We have recently generated a mouse model of squamous lung carcinoma by overexpressing Sex-determining region Y-box 2 (Sox2) and deleting liver kinase B1 (Lkb1) using a lentiviral approach. This model recap...

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Autores principales: Mukhopadhyay, Anandaroop, Oliver, Trudy G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904963/
https://www.ncbi.nlm.nih.gov/pubmed/27308419
http://dx.doi.org/10.4161/23723548.2014.969651
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author Mukhopadhyay, Anandaroop
Oliver, Trudy G
author_facet Mukhopadhyay, Anandaroop
Oliver, Trudy G
author_sort Mukhopadhyay, Anandaroop
collection PubMed
description Squamous lung cancer is a subtype of non-small cell lung cancer with a poor overall prognosis. We have recently generated a mouse model of squamous lung carcinoma by overexpressing Sex-determining region Y-box 2 (Sox2) and deleting liver kinase B1 (Lkb1) using a lentiviral approach. This model recapitulates the human disease in terms of histopathology, biomarker expression, and signaling pathway activation, making it an excellent model for preclinical studies.
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spelling pubmed-49049632016-06-15 Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer Mukhopadhyay, Anandaroop Oliver, Trudy G Mol Cell Oncol Author'S View Squamous lung cancer is a subtype of non-small cell lung cancer with a poor overall prognosis. We have recently generated a mouse model of squamous lung carcinoma by overexpressing Sex-determining region Y-box 2 (Sox2) and deleting liver kinase B1 (Lkb1) using a lentiviral approach. This model recapitulates the human disease in terms of histopathology, biomarker expression, and signaling pathway activation, making it an excellent model for preclinical studies. Taylor & Francis 2014-11-11 /pmc/articles/PMC4904963/ /pubmed/27308419 http://dx.doi.org/10.4161/23723548.2014.969651 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Mukhopadhyay, Anandaroop
Oliver, Trudy G
Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer
title Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer
title_full Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer
title_fullStr Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer
title_full_unstemmed Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer
title_short Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer
title_sort mighty mouse breakthroughs: a sox2-driven model for squamous cell lung cancer
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904963/
https://www.ncbi.nlm.nih.gov/pubmed/27308419
http://dx.doi.org/10.4161/23723548.2014.969651
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