Dysregulation of HIF2α and autophagy in renal cell carcinoma

Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of diff...

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Detalles Bibliográficos
Autores principales: Liu, Xian-De, Zhu, Haifeng, DePavia, Adela, Jonasch, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904964/
https://www.ncbi.nlm.nih.gov/pubmed/27308417
http://dx.doi.org/10.4161/23723548.2014.965643
Descripción
Sumario:Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of different subtypes of renal cell carcinoma (RCC).

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