Dysregulation of HIF2α and autophagy in renal cell carcinoma

Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of diff...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xian-De, Zhu, Haifeng, DePavia, Adela, Jonasch, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904964/
https://www.ncbi.nlm.nih.gov/pubmed/27308417
http://dx.doi.org/10.4161/23723548.2014.965643
_version_ 1782437209127780352
author Liu, Xian-De
Zhu, Haifeng
DePavia, Adela
Jonasch, Eric
author_facet Liu, Xian-De
Zhu, Haifeng
DePavia, Adela
Jonasch, Eric
author_sort Liu, Xian-De
collection PubMed
description Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of different subtypes of renal cell carcinoma (RCC).
format Online
Article
Text
id pubmed-4904964
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49049642016-06-15 Dysregulation of HIF2α and autophagy in renal cell carcinoma Liu, Xian-De Zhu, Haifeng DePavia, Adela Jonasch, Eric Mol Cell Oncol Author'S View Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of different subtypes of renal cell carcinoma (RCC). Taylor & Francis 2014-10-30 /pmc/articles/PMC4904964/ /pubmed/27308417 http://dx.doi.org/10.4161/23723548.2014.965643 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Liu, Xian-De
Zhu, Haifeng
DePavia, Adela
Jonasch, Eric
Dysregulation of HIF2α and autophagy in renal cell carcinoma
title Dysregulation of HIF2α and autophagy in renal cell carcinoma
title_full Dysregulation of HIF2α and autophagy in renal cell carcinoma
title_fullStr Dysregulation of HIF2α and autophagy in renal cell carcinoma
title_full_unstemmed Dysregulation of HIF2α and autophagy in renal cell carcinoma
title_short Dysregulation of HIF2α and autophagy in renal cell carcinoma
title_sort dysregulation of hif2α and autophagy in renal cell carcinoma
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904964/
https://www.ncbi.nlm.nih.gov/pubmed/27308417
http://dx.doi.org/10.4161/23723548.2014.965643
work_keys_str_mv AT liuxiande dysregulationofhif2aandautophagyinrenalcellcarcinoma
AT zhuhaifeng dysregulationofhif2aandautophagyinrenalcellcarcinoma
AT depaviaadela dysregulationofhif2aandautophagyinrenalcellcarcinoma
AT jonascheric dysregulationofhif2aandautophagyinrenalcellcarcinoma

Ejemplares similares