A cancerous web: signaling, metabolism, and the epigenome

Histone acetylation is sensitive to the availability of acetyl-CoA. However, the extent to which metabolic alterations in cancer cells impact tumor histone acetylation has been unclear. Here, we discuss our recent findings that oncogenic AKT1 activation regulates histone acetylation levels in tumors...

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Detalles Bibliográficos
Autores principales: Lee, Joyce V., Shah, Supriya, Carrer, Alessandro, Wellen, Kathryn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904988/
https://www.ncbi.nlm.nih.gov/pubmed/27308412
http://dx.doi.org/10.4161/23723548.2014.965620
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author Lee, Joyce V.
Shah, Supriya
Carrer, Alessandro
Wellen, Kathryn E.
author_facet Lee, Joyce V.
Shah, Supriya
Carrer, Alessandro
Wellen, Kathryn E.
author_sort Lee, Joyce V.
collection PubMed
description Histone acetylation is sensitive to the availability of acetyl-CoA. However, the extent to which metabolic alterations in cancer cells impact tumor histone acetylation has been unclear. Here, we discuss our recent findings that oncogenic AKT1 activation regulates histone acetylation levels in tumors through regulation of acetyl-CoA metabolism.
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spelling pubmed-49049882016-06-15 A cancerous web: signaling, metabolism, and the epigenome Lee, Joyce V. Shah, Supriya Carrer, Alessandro Wellen, Kathryn E. Mol Cell Oncol Author'S View Histone acetylation is sensitive to the availability of acetyl-CoA. However, the extent to which metabolic alterations in cancer cells impact tumor histone acetylation has been unclear. Here, we discuss our recent findings that oncogenic AKT1 activation regulates histone acetylation levels in tumors through regulation of acetyl-CoA metabolism. Taylor & Francis 2014-10-30 /pmc/articles/PMC4904988/ /pubmed/27308412 http://dx.doi.org/10.4161/23723548.2014.965620 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Lee, Joyce V.
Shah, Supriya
Carrer, Alessandro
Wellen, Kathryn E.
A cancerous web: signaling, metabolism, and the epigenome
title A cancerous web: signaling, metabolism, and the epigenome
title_full A cancerous web: signaling, metabolism, and the epigenome
title_fullStr A cancerous web: signaling, metabolism, and the epigenome
title_full_unstemmed A cancerous web: signaling, metabolism, and the epigenome
title_short A cancerous web: signaling, metabolism, and the epigenome
title_sort cancerous web: signaling, metabolism, and the epigenome
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904988/
https://www.ncbi.nlm.nih.gov/pubmed/27308412
http://dx.doi.org/10.4161/23723548.2014.965620
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