Do changes in the c-MYC coding sequence contribute to tumorigenesis?

The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that disparate tumor-associated mutations in c-MYC have similar pro...

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Autores principales: Chakraborty, Abhishek A., Tansey, William P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904990/
https://www.ncbi.nlm.nih.gov/pubmed/27308414
http://dx.doi.org/10.4161/23723548.2014.965631
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author Chakraborty, Abhishek A.
Tansey, William P.
author_facet Chakraborty, Abhishek A.
Tansey, William P.
author_sort Chakraborty, Abhishek A.
collection PubMed
description The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that disparate tumor-associated mutations in c-MYC have similar protumorigenic effects suggests that these mutations contribute directly to malignancy.
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spelling pubmed-49049902016-06-15 Do changes in the c-MYC coding sequence contribute to tumorigenesis? Chakraborty, Abhishek A. Tansey, William P. Mol Cell Oncol Author'S View The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that disparate tumor-associated mutations in c-MYC have similar protumorigenic effects suggests that these mutations contribute directly to malignancy. Taylor & Francis 2014-10-30 /pmc/articles/PMC4904990/ /pubmed/27308414 http://dx.doi.org/10.4161/23723548.2014.965631 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Chakraborty, Abhishek A.
Tansey, William P.
Do changes in the c-MYC coding sequence contribute to tumorigenesis?
title Do changes in the c-MYC coding sequence contribute to tumorigenesis?
title_full Do changes in the c-MYC coding sequence contribute to tumorigenesis?
title_fullStr Do changes in the c-MYC coding sequence contribute to tumorigenesis?
title_full_unstemmed Do changes in the c-MYC coding sequence contribute to tumorigenesis?
title_short Do changes in the c-MYC coding sequence contribute to tumorigenesis?
title_sort do changes in the c-myc coding sequence contribute to tumorigenesis?
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904990/
https://www.ncbi.nlm.nih.gov/pubmed/27308414
http://dx.doi.org/10.4161/23723548.2014.965631
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