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Do changes in the c-MYC coding sequence contribute to tumorigenesis?

The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that disparate tumor-associated mutations in c-MYC have similar pro...

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Detalles Bibliográficos
Autores principales:	Chakraborty, Abhishek A., Tansey, William P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Author'S View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904990/ https://www.ncbi.nlm.nih.gov/pubmed/27308414 http://dx.doi.org/10.4161/23723548.2014.965631

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