Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells “it's time to die”

The discovery that inhibition of a circadian regulator enhances autophagy-dependent cancer cell death reveals potential avenues for the development of new multifunctional anticancer agents. Further studies may elucidate novel crosstalk between circadian rhythm, metabolism, and autophagy that determi...

Descripción completa

Detalles Bibliográficos
Autor principal: Grimaldi, Benedetto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904992/
https://www.ncbi.nlm.nih.gov/pubmed/27308413
http://dx.doi.org/10.4161/23723548.2014.965626
_version_ 1782437210260242432
author Grimaldi, Benedetto
author_facet Grimaldi, Benedetto
author_sort Grimaldi, Benedetto
collection PubMed
description The discovery that inhibition of a circadian regulator enhances autophagy-dependent cancer cell death reveals potential avenues for the development of new multifunctional anticancer agents. Further studies may elucidate novel crosstalk between circadian rhythm, metabolism, and autophagy that determines cancer cell viability.
format Online
Article
Text
id pubmed-4904992
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49049922016-06-15 Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells “it's time to die” Grimaldi, Benedetto Mol Cell Oncol Author'S View The discovery that inhibition of a circadian regulator enhances autophagy-dependent cancer cell death reveals potential avenues for the development of new multifunctional anticancer agents. Further studies may elucidate novel crosstalk between circadian rhythm, metabolism, and autophagy that determines cancer cell viability. Taylor & Francis 2014-10-30 /pmc/articles/PMC4904992/ /pubmed/27308413 http://dx.doi.org/10.4161/23723548.2014.965626 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Grimaldi, Benedetto
Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells “it's time to die”
title Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells “it's time to die”
title_full Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells “it's time to die”
title_fullStr Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells “it's time to die”
title_full_unstemmed Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells “it's time to die”
title_short Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells “it's time to die”
title_sort lysosomotropic rev-erb antagonism: a metabolic connection between circadian rhythm and autophagy may tell cancer cells “it's time to die”
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904992/
https://www.ncbi.nlm.nih.gov/pubmed/27308413
http://dx.doi.org/10.4161/23723548.2014.965626
work_keys_str_mv AT grimaldibenedetto lysosomotropicreverbantagonismametabolicconnectionbetweencircadianrhythmandautophagymaytellcancercellsitstimetodie

Ejemplares similares