Reactive oxygen species: The good, the bad, and the enigma

Work carried out primarily in the laboratory of Fabrizio d’Adda di Fagagna unveils the mitogenic properties of Ras-induced reactive oxygen species (ROS) and their relationship with the DNA damage response. Combined data from studies of cultured cells, zebrafish models, and clinical material consiste...

Descripción completa

Detalles Bibliográficos
Autor principal: Ogrunc, Müge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904994/
https://www.ncbi.nlm.nih.gov/pubmed/27308352
http://dx.doi.org/10.4161/23723548.2014.964033
_version_ 1782437210700644352
author Ogrunc, Müge
author_facet Ogrunc, Müge
author_sort Ogrunc, Müge
collection PubMed
description Work carried out primarily in the laboratory of Fabrizio d’Adda di Fagagna unveils the mitogenic properties of Ras-induced reactive oxygen species (ROS) and their relationship with the DNA damage response. Combined data from studies of cultured cells, zebrafish models, and clinical material consistently support a role of the RAS-RAC1-NOX4 axis in ROS induction, hyperproliferation, and senescence.
format Online
Article
Text
id pubmed-4904994
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49049942016-06-15 Reactive oxygen species: The good, the bad, and the enigma Ogrunc, Müge Mol Cell Oncol Author's View Work carried out primarily in the laboratory of Fabrizio d’Adda di Fagagna unveils the mitogenic properties of Ras-induced reactive oxygen species (ROS) and their relationship with the DNA damage response. Combined data from studies of cultured cells, zebrafish models, and clinical material consistently support a role of the RAS-RAC1-NOX4 axis in ROS induction, hyperproliferation, and senescence. Taylor & Francis 2014-12-23 /pmc/articles/PMC4904994/ /pubmed/27308352 http://dx.doi.org/10.4161/23723548.2014.964033 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Ogrunc, Müge
Reactive oxygen species: The good, the bad, and the enigma
title Reactive oxygen species: The good, the bad, and the enigma
title_full Reactive oxygen species: The good, the bad, and the enigma
title_fullStr Reactive oxygen species: The good, the bad, and the enigma
title_full_unstemmed Reactive oxygen species: The good, the bad, and the enigma
title_short Reactive oxygen species: The good, the bad, and the enigma
title_sort reactive oxygen species: the good, the bad, and the enigma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904994/
https://www.ncbi.nlm.nih.gov/pubmed/27308352
http://dx.doi.org/10.4161/23723548.2014.964033
work_keys_str_mv AT ogruncmuge reactiveoxygenspeciesthegoodthebadandtheenigma

Ejemplares similares