WWOX loss activates aerobic glycolysis

Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tu...

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Autores principales: Abu-Remaileh, Muhannad, Seewaldt, Victoria L, Aqeilan, Rami I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904998/
https://www.ncbi.nlm.nih.gov/pubmed/27308416
http://dx.doi.org/10.4161/23723548.2014.965640
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author Abu-Remaileh, Muhannad
Seewaldt, Victoria L
Aqeilan, Rami I
author_facet Abu-Remaileh, Muhannad
Seewaldt, Victoria L
Aqeilan, Rami I
author_sort Abu-Remaileh, Muhannad
collection PubMed
description Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.
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spelling pubmed-49049982016-06-15 WWOX loss activates aerobic glycolysis Abu-Remaileh, Muhannad Seewaldt, Victoria L Aqeilan, Rami I Mol Cell Oncol Commentary Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state. Taylor & Francis 2014-10-30 /pmc/articles/PMC4904998/ /pubmed/27308416 http://dx.doi.org/10.4161/23723548.2014.965640 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Abu-Remaileh, Muhannad
Seewaldt, Victoria L
Aqeilan, Rami I
WWOX loss activates aerobic glycolysis
title WWOX loss activates aerobic glycolysis
title_full WWOX loss activates aerobic glycolysis
title_fullStr WWOX loss activates aerobic glycolysis
title_full_unstemmed WWOX loss activates aerobic glycolysis
title_short WWOX loss activates aerobic glycolysis
title_sort wwox loss activates aerobic glycolysis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904998/
https://www.ncbi.nlm.nih.gov/pubmed/27308416
http://dx.doi.org/10.4161/23723548.2014.965640
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