Microtubule plus tips: A dynamic route to chromosomal instability

Although chromosomal instability (CIN) is a recognized hallmark of cancer the underlying mechanisms and consequences are largely unknown. However, it is accepted that lagging chromosomes represent a major prerequisite for chromosome missegregation in cancer cells. Here, we discuss how lagging chromo...

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Detalles Bibliográficos
Autores principales: Stolz, Ailine, Ertych, Norman, Bastians, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905025/
https://www.ncbi.nlm.nih.gov/pubmed/27308411
http://dx.doi.org/10.4161/23723548.2014.960768
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author Stolz, Ailine
Ertych, Norman
Bastians, Holger
author_facet Stolz, Ailine
Ertych, Norman
Bastians, Holger
author_sort Stolz, Ailine
collection PubMed
description Although chromosomal instability (CIN) is a recognized hallmark of cancer the underlying mechanisms and consequences are largely unknown. However, it is accepted that lagging chromosomes represent a major prerequisite for chromosome missegregation in cancer cells. Here, we discuss how lagging chromosomes are generated and our recent findings establishing increased microtubule assembly rates as a source of CIN.
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spelling pubmed-49050252016-06-15 Microtubule plus tips: A dynamic route to chromosomal instability Stolz, Ailine Ertych, Norman Bastians, Holger Mol Cell Oncol Author'S View Although chromosomal instability (CIN) is a recognized hallmark of cancer the underlying mechanisms and consequences are largely unknown. However, it is accepted that lagging chromosomes represent a major prerequisite for chromosome missegregation in cancer cells. Here, we discuss how lagging chromosomes are generated and our recent findings establishing increased microtubule assembly rates as a source of CIN. Taylor & Francis 2014-10-29 /pmc/articles/PMC4905025/ /pubmed/27308411 http://dx.doi.org/10.4161/23723548.2014.960768 Text en © 2015 Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Stolz, Ailine
Ertych, Norman
Bastians, Holger
Microtubule plus tips: A dynamic route to chromosomal instability
title Microtubule plus tips: A dynamic route to chromosomal instability
title_full Microtubule plus tips: A dynamic route to chromosomal instability
title_fullStr Microtubule plus tips: A dynamic route to chromosomal instability
title_full_unstemmed Microtubule plus tips: A dynamic route to chromosomal instability
title_short Microtubule plus tips: A dynamic route to chromosomal instability
title_sort microtubule plus tips: a dynamic route to chromosomal instability
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905025/
https://www.ncbi.nlm.nih.gov/pubmed/27308411
http://dx.doi.org/10.4161/23723548.2014.960768
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AT ertychnorman microtubuleplustipsadynamicroutetochromosomalinstability
AT bastiansholger microtubuleplustipsadynamicroutetochromosomalinstability

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