PTP1B: mediating ROS signaling to silence genes

Numerous studies have shown that normal cells often respond to the activation of oncogenes by undergoing reactive oxygen species-dependent induction of senescence. Here, we discuss our recent publication identifying protein tyrosine phosphatase PTP1B as an important redox-controlled checkpoint for s...

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Detalles Bibliográficos
Autores principales: Boivin, Benoit, Tonks, Nicholas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905060/
https://www.ncbi.nlm.nih.gov/pubmed/27308433
http://dx.doi.org/10.4161/23723556.2014.975633
Descripción
Sumario:Numerous studies have shown that normal cells often respond to the activation of oncogenes by undergoing reactive oxygen species-dependent induction of senescence. Here, we discuss our recent publication identifying protein tyrosine phosphatase PTP1B as an important redox-controlled checkpoint for senescence downstream of oncogenic RAS.

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