PTP1B: mediating ROS signaling to silence genes

Numerous studies have shown that normal cells often respond to the activation of oncogenes by undergoing reactive oxygen species-dependent induction of senescence. Here, we discuss our recent publication identifying protein tyrosine phosphatase PTP1B as an important redox-controlled checkpoint for s...

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Detalles Bibliográficos
Autores principales: Boivin, Benoit, Tonks, Nicholas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905060/
https://www.ncbi.nlm.nih.gov/pubmed/27308433
http://dx.doi.org/10.4161/23723556.2014.975633
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author Boivin, Benoit
Tonks, Nicholas K.
author_facet Boivin, Benoit
Tonks, Nicholas K.
author_sort Boivin, Benoit
collection PubMed
description Numerous studies have shown that normal cells often respond to the activation of oncogenes by undergoing reactive oxygen species-dependent induction of senescence. Here, we discuss our recent publication identifying protein tyrosine phosphatase PTP1B as an important redox-controlled checkpoint for senescence downstream of oncogenic RAS.
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spelling pubmed-49050602016-06-15 PTP1B: mediating ROS signaling to silence genes Boivin, Benoit Tonks, Nicholas K. Mol Cell Oncol Author'S View Numerous studies have shown that normal cells often respond to the activation of oncogenes by undergoing reactive oxygen species-dependent induction of senescence. Here, we discuss our recent publication identifying protein tyrosine phosphatase PTP1B as an important redox-controlled checkpoint for senescence downstream of oncogenic RAS. Taylor & Francis 2015-02-26 /pmc/articles/PMC4905060/ /pubmed/27308433 http://dx.doi.org/10.4161/23723556.2014.975633 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Boivin, Benoit
Tonks, Nicholas K.
PTP1B: mediating ROS signaling to silence genes
title PTP1B: mediating ROS signaling to silence genes
title_full PTP1B: mediating ROS signaling to silence genes
title_fullStr PTP1B: mediating ROS signaling to silence genes
title_full_unstemmed PTP1B: mediating ROS signaling to silence genes
title_short PTP1B: mediating ROS signaling to silence genes
title_sort ptp1b: mediating ros signaling to silence genes
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905060/
https://www.ncbi.nlm.nih.gov/pubmed/27308433
http://dx.doi.org/10.4161/23723556.2014.975633
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