Cargando…

Prevalence and Determinants of True Thyroid Dysfunction Among Pediatric Referrals for Abnormal Thyroid Function Tests

Background/Aims. Abnormalities in thyroid function tests (TFTs) are a common referral reason for pediatric endocrine evaluation. However, a sizable proportion of these laboratory abnormalities do not warrant therapy or endocrine follow-up. The objectives of this study were (a) to evaluate the preval...

Descripción completa

Detalles Bibliográficos
Autores principales: Lahoti, Amit, Klein, Jason, Schumaker, Tiffany, Vuguin, Patricia, Frank, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905146/
https://www.ncbi.nlm.nih.gov/pubmed/27336020
http://dx.doi.org/10.1177/2333794X16646701
_version_ 1782437217065500672
author Lahoti, Amit
Klein, Jason
Schumaker, Tiffany
Vuguin, Patricia
Frank, Graeme
author_facet Lahoti, Amit
Klein, Jason
Schumaker, Tiffany
Vuguin, Patricia
Frank, Graeme
author_sort Lahoti, Amit
collection PubMed
description Background/Aims. Abnormalities in thyroid function tests (TFTs) are a common referral reason for pediatric endocrine evaluation. However, a sizable proportion of these laboratory abnormalities do not warrant therapy or endocrine follow-up. The objectives of this study were (a) to evaluate the prevalence of true thyroid dysfunction among pediatric endocrinology referrals for abnormal TFTs; (b) to identify the historical, clinical, and laboratory characteristics that predict decision to treat. Methods. This was a retrospective chart review of patients evaluated in pediatric endocrinology office during a weekly clinic designated for new referrals for abnormal TFTs in 2010. Results. A total of 230 patients were included in the study. Median age at referral was 12 years (range = 2-18); 56% were females. Routine screening was cited as the reason for performing TFTs by 33% patients. Majority was evaluated for hypothyroidism (n = 206). Elevated thyroid-stimulating hormone was the most common referral reason (n = 140). A total of 41 out of 206 patients were treated for hypothyroidism. Conclusions. Prevalence of hypothyroidism was 20%. Thyroid follow-up was not recommended for nearly one third of the patients. Among all the factors analyzed, an elevated thyroid-stimulating hormone level and antithyroglobulin antibodies strongly correlated with the decision to treat (P < .005).
format Online
Article
Text
id pubmed-4905146
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-49051462016-06-22 Prevalence and Determinants of True Thyroid Dysfunction Among Pediatric Referrals for Abnormal Thyroid Function Tests Lahoti, Amit Klein, Jason Schumaker, Tiffany Vuguin, Patricia Frank, Graeme Glob Pediatr Health Original Article Background/Aims. Abnormalities in thyroid function tests (TFTs) are a common referral reason for pediatric endocrine evaluation. However, a sizable proportion of these laboratory abnormalities do not warrant therapy or endocrine follow-up. The objectives of this study were (a) to evaluate the prevalence of true thyroid dysfunction among pediatric endocrinology referrals for abnormal TFTs; (b) to identify the historical, clinical, and laboratory characteristics that predict decision to treat. Methods. This was a retrospective chart review of patients evaluated in pediatric endocrinology office during a weekly clinic designated for new referrals for abnormal TFTs in 2010. Results. A total of 230 patients were included in the study. Median age at referral was 12 years (range = 2-18); 56% were females. Routine screening was cited as the reason for performing TFTs by 33% patients. Majority was evaluated for hypothyroidism (n = 206). Elevated thyroid-stimulating hormone was the most common referral reason (n = 140). A total of 41 out of 206 patients were treated for hypothyroidism. Conclusions. Prevalence of hypothyroidism was 20%. Thyroid follow-up was not recommended for nearly one third of the patients. Among all the factors analyzed, an elevated thyroid-stimulating hormone level and antithyroglobulin antibodies strongly correlated with the decision to treat (P < .005). SAGE Publications 2016-05-05 /pmc/articles/PMC4905146/ /pubmed/27336020 http://dx.doi.org/10.1177/2333794X16646701 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Lahoti, Amit
Klein, Jason
Schumaker, Tiffany
Vuguin, Patricia
Frank, Graeme
Prevalence and Determinants of True Thyroid Dysfunction Among Pediatric Referrals for Abnormal Thyroid Function Tests
title Prevalence and Determinants of True Thyroid Dysfunction Among Pediatric Referrals for Abnormal Thyroid Function Tests
title_full Prevalence and Determinants of True Thyroid Dysfunction Among Pediatric Referrals for Abnormal Thyroid Function Tests
title_fullStr Prevalence and Determinants of True Thyroid Dysfunction Among Pediatric Referrals for Abnormal Thyroid Function Tests
title_full_unstemmed Prevalence and Determinants of True Thyroid Dysfunction Among Pediatric Referrals for Abnormal Thyroid Function Tests
title_short Prevalence and Determinants of True Thyroid Dysfunction Among Pediatric Referrals for Abnormal Thyroid Function Tests
title_sort prevalence and determinants of true thyroid dysfunction among pediatric referrals for abnormal thyroid function tests
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905146/
https://www.ncbi.nlm.nih.gov/pubmed/27336020
http://dx.doi.org/10.1177/2333794X16646701
work_keys_str_mv AT lahotiamit prevalenceanddeterminantsoftruethyroiddysfunctionamongpediatricreferralsforabnormalthyroidfunctiontests
AT kleinjason prevalenceanddeterminantsoftruethyroiddysfunctionamongpediatricreferralsforabnormalthyroidfunctiontests
AT schumakertiffany prevalenceanddeterminantsoftruethyroiddysfunctionamongpediatricreferralsforabnormalthyroidfunctiontests
AT vuguinpatricia prevalenceanddeterminantsoftruethyroiddysfunctionamongpediatricreferralsforabnormalthyroidfunctiontests
AT frankgraeme prevalenceanddeterminantsoftruethyroiddysfunctionamongpediatricreferralsforabnormalthyroidfunctiontests