Execution of RIPK3-regulated necrosis

Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis. The newly identified MLKL...

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Detalles Bibliográficos
Autores principales: Cai, Zhenyu, Liu, Zheng-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905176/
https://www.ncbi.nlm.nih.gov/pubmed/27308332
http://dx.doi.org/10.4161/23723548.2014.960759
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author Cai, Zhenyu
Liu, Zheng-Gang
author_facet Cai, Zhenyu
Liu, Zheng-Gang
author_sort Cai, Zhenyu
collection PubMed
description Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis. The newly identified MLKL protein functions downstream of RIP1/RIP3 and is essential for the execution of necroptosis. Studies also indicate involvement of reactive oxygen species and calcium and sodium ions. Identification of the key mediators of necroptosis is critical for understanding the molecular mechanisms of the necroptotic process.
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spelling pubmed-49051762016-06-15 Execution of RIPK3-regulated necrosis Cai, Zhenyu Liu, Zheng-Gang Mol Cell Oncol Review Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis. The newly identified MLKL protein functions downstream of RIP1/RIP3 and is essential for the execution of necroptosis. Studies also indicate involvement of reactive oxygen species and calcium and sodium ions. Identification of the key mediators of necroptosis is critical for understanding the molecular mechanisms of the necroptotic process. Taylor & Francis 2014-10-29 /pmc/articles/PMC4905176/ /pubmed/27308332 http://dx.doi.org/10.4161/23723548.2014.960759 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Cai, Zhenyu
Liu, Zheng-Gang
Execution of RIPK3-regulated necrosis
title Execution of RIPK3-regulated necrosis
title_full Execution of RIPK3-regulated necrosis
title_fullStr Execution of RIPK3-regulated necrosis
title_full_unstemmed Execution of RIPK3-regulated necrosis
title_short Execution of RIPK3-regulated necrosis
title_sort execution of ripk3-regulated necrosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905176/
https://www.ncbi.nlm.nih.gov/pubmed/27308332
http://dx.doi.org/10.4161/23723548.2014.960759
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