Regulation of cancer stem-like cell differentiation by Smac mimetics

Small-molecule antagonists of inhibitor of apoptosis (IAP) proteins such as Smac mimetics are considered promising cancer therapeutics through the engagement of cell death pathways. Recent evidence suggests that Smac mimetics perform additional nonapoptotic functions by initiating differentiation in...

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Detalles Bibliográficos
Autor principal: Fulda, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905178/
https://www.ncbi.nlm.nih.gov/pubmed/27308334
http://dx.doi.org/10.4161/23723548.2014.960769
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author Fulda, Simone
author_facet Fulda, Simone
author_sort Fulda, Simone
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description Small-molecule antagonists of inhibitor of apoptosis (IAP) proteins such as Smac mimetics are considered promising cancer therapeutics through the engagement of cell death pathways. Recent evidence suggests that Smac mimetics perform additional nonapoptotic functions by initiating differentiation in cancer stem-like cells, opening new perspectives for their future clinical application.
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spelling pubmed-49051782016-06-15 Regulation of cancer stem-like cell differentiation by Smac mimetics Fulda, Simone Mol Cell Oncol Author's View Small-molecule antagonists of inhibitor of apoptosis (IAP) proteins such as Smac mimetics are considered promising cancer therapeutics through the engagement of cell death pathways. Recent evidence suggests that Smac mimetics perform additional nonapoptotic functions by initiating differentiation in cancer stem-like cells, opening new perspectives for their future clinical application. Taylor & Francis 2014-10-29 /pmc/articles/PMC4905178/ /pubmed/27308334 http://dx.doi.org/10.4161/23723548.2014.960769 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Fulda, Simone
Regulation of cancer stem-like cell differentiation by Smac mimetics
title Regulation of cancer stem-like cell differentiation by Smac mimetics
title_full Regulation of cancer stem-like cell differentiation by Smac mimetics
title_fullStr Regulation of cancer stem-like cell differentiation by Smac mimetics
title_full_unstemmed Regulation of cancer stem-like cell differentiation by Smac mimetics
title_short Regulation of cancer stem-like cell differentiation by Smac mimetics
title_sort regulation of cancer stem-like cell differentiation by smac mimetics
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905178/
https://www.ncbi.nlm.nih.gov/pubmed/27308334
http://dx.doi.org/10.4161/23723548.2014.960769
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