Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1

During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrupts this balance in favor of the transforming effect of oncog...

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Detalles Bibliográficos
Autores principales: Grasso, Daniel, Garcia, Maria Noé, Hamidi, Tewfik, Cano, Carla, Calvo, Ezequiel, Lomberk, Gwen, Urrutia, Raul, Iovanna, Juan L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905183/
https://www.ncbi.nlm.nih.gov/pubmed/27308320
http://dx.doi.org/10.4161/mco.29913
Descripción
Sumario:During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrupts this balance in favor of the transforming effect of oncogenes by lowering the tumor suppressive threshold of oncogene-induced senescence through expression of the stress protein Nupr1.

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