Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1

During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrupts this balance in favor of the transforming effect of oncog...

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Autores principales: Grasso, Daniel, Garcia, Maria Noé, Hamidi, Tewfik, Cano, Carla, Calvo, Ezequiel, Lomberk, Gwen, Urrutia, Raul, Iovanna, Juan L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905183/
https://www.ncbi.nlm.nih.gov/pubmed/27308320
http://dx.doi.org/10.4161/mco.29913
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author Grasso, Daniel
Garcia, Maria Noé
Hamidi, Tewfik
Cano, Carla
Calvo, Ezequiel
Lomberk, Gwen
Urrutia, Raul
Iovanna, Juan L
author_facet Grasso, Daniel
Garcia, Maria Noé
Hamidi, Tewfik
Cano, Carla
Calvo, Ezequiel
Lomberk, Gwen
Urrutia, Raul
Iovanna, Juan L
author_sort Grasso, Daniel
collection PubMed
description During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrupts this balance in favor of the transforming effect of oncogenes by lowering the tumor suppressive threshold of oncogene-induced senescence through expression of the stress protein Nupr1.
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spelling pubmed-49051832016-06-15 Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1 Grasso, Daniel Garcia, Maria Noé Hamidi, Tewfik Cano, Carla Calvo, Ezequiel Lomberk, Gwen Urrutia, Raul Iovanna, Juan L Mol Cell Oncol Review During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrupts this balance in favor of the transforming effect of oncogenes by lowering the tumor suppressive threshold of oncogene-induced senescence through expression of the stress protein Nupr1. Taylor & Francis 2014-07-28 /pmc/articles/PMC4905183/ /pubmed/27308320 http://dx.doi.org/10.4161/mco.29913 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Grasso, Daniel
Garcia, Maria Noé
Hamidi, Tewfik
Cano, Carla
Calvo, Ezequiel
Lomberk, Gwen
Urrutia, Raul
Iovanna, Juan L
Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1
title Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1
title_full Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1
title_fullStr Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1
title_full_unstemmed Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1
title_short Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1
title_sort pancreatitis promotes oncogenic kras(g12d)-induced pancreatic transformation through activation of nupr1
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905183/
https://www.ncbi.nlm.nih.gov/pubmed/27308320
http://dx.doi.org/10.4161/mco.29913
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