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Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1
During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrupts this balance in favor of the transforming effect of oncog...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905183/ https://www.ncbi.nlm.nih.gov/pubmed/27308320 http://dx.doi.org/10.4161/mco.29913 |